ABSTRACT

Objective

To assess whether the Rey Auditory Verbal Learning Test (RAVLT) could differentiate deterioration from Mild Cognitive Impairment (MCI) to dementia.

Methods

Twenty-six participants who were diagnosed with MCI performed the RAVLT and the Mini Mental State Examination (MMSE) at baseline and after nearly a decade (M = 8.8 years, SD = 3.16), in order to evaluate whether they progressed to dementia.

Results

Twelve participants [5 males, 7 females; age M = 63.7 (7.7)] kept their diagnoses of MCI; 14 participants [11 males, 3 females; age M = 75.0 (6.5)] converted to dementia. Both groups had similar MMSE scores at baseline [26.6 (0.6); and 26.6 (0.7) respectively]. Significant differences between dementia and MCI groups were found on most measures of the RAVLT at baseline: Immediate memory [p = .04], delayed recall [p = .003], total learning [p = .01], learning rate [p = .002], retrieval efficiency [p = .004], and false alarms [p = .004]. Thus, the RAVLT results were significantly worse at baseline in those who later converted. The results remain the same when controlling for age.

Conclusion

The results extend previous findings with follow-up of nearly a decade demonstrating that most of the RAVLT measures are sensitive to differentiate conversion from MCI to dementia.

中文翻译：

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RAVLT 能否预测从 MCI 到痴呆症的恶化？长期随访数据

摘要

客观的

评估 Rey 听觉言语学习测试 (RAVLT) 是否可以区分从轻度认知障碍 (MCI) 到痴呆症的恶化。

方法

26 名被诊断为 MCI 的参与者在基线和近十年后（M = 8.8 年，SD = 3.16）进行了 RAVLT 和迷你精神状态检查 (MMSE)，以评估他们是否进展为痴呆症。

结果

12名参与者[男性5名，女性7名；年龄 M = 63.7 (7.7)] 保留了他们对 MCI 的诊断；14 名参与者 [11 名男性，3 名女性；年龄 M = 75.0 (6.5)] 转为痴呆。两组在基线时的 MMSE 评分相似 [26.6 (0.6); 和 26.6 (0.7)]。在基线 RAVLT 的大多数测量中发现痴呆和 MCI 组之间存在显着差异：即刻记忆 [ p = .04]、延迟回忆 [ p = .003]、总学习 [ p = .01]、学习率 [ p = .002]、检索效率 [ p = .004] 和误报 [ p = .004]。因此，在后来转换的人中，RAVLT 结果在基线时明显更差。在控制年龄时，结果保持不变。

结论

结果通过近十年的随访扩展了先前的发现，表明大多数 RAVLT 测量对区分从 MCI 到痴呆的转换很敏感。