Abstract

The aim of the study was to compare the effects of a lacto-ovo-vegetarian diet (LOV-D) vs. a standard weight-loss diet (SWL-D) on obese/overweight adults with NAFLD. Present randomised clinical trial recruited 75 overweight/obese adults with NAFLD, who were randomly assigned into LOV-D and SWL-D groups for 3 months. The LOV-D was designed based on eliminating meat, poultry, and fish; while including dairy products and eggs. The SWL-D was planned according to the standard food pyramid, which was free in all sources of food. Adherence to LOV-D significantly outperformed SWL-D in reducing levels of alanine aminotransferase (ALT), body weight, waist circumference, BMI, fasting blood sugar, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP). Furthermore, ultrasonography revealed a higher alleviation in NAFLD grade among LOV-D, compared with SWL-D. This study suggests that adherence to LOV-D for 3 months has beneficial effects on NAFLD improvement, anthropometric measures, glycaemic-related markers, and lipid profiles.

摘要

该研究的目的是比较乳蛋素饮食 (LOV-D)与标准减肥饮食 (SWL-D) 对患有 NAFLD 的肥胖/超重成人的影响。目前的随机临床试验招募了 75 名患有 NAFLD 的超重/肥胖成年人，他们被随机分为 LOV-D 和 SWL-D 组，为期 3 个月。LOV-D 的设计基于消除肉类、家禽和鱼类；同时包括乳制品和鸡蛋。SWL-D 是根据标准食物金字塔规划的，所有食物来源都是免费的。坚持LOV-D在降低丙氨酸氨基转移酶（ALT）、体重、腰围、BMI、空腹血糖、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、三酰甘油（TG）水平方面显着优于SWL-D 、胆固醇、低密度脂蛋白胆固醇（LDL-C）和收缩压（SBP）。此外，超声检查显示，与 SWL-D 相比，LOV-D 的 NAFLD 等级减轻程度更高。这项研究表明，坚持使用 LOV-D 3 个月对 NAFLD 改善、人体测量、血糖相关标志物和血脂状况具有有益影响。