Elevated autophagy is highly associated with cancer development and progression. Fruit extracts of several plants inhibit activity of autophagy‐related protease ATG4B and autophagy activity in colorectal cancer cells. However, the effects of these plant extracts in oral cancer cells remain unclear. In this study, we found that the extracted Tribulus terrestris fruit (TT‐(fr)) and Xanthium strumarium fruit had inhibitory effects on autophagy inhibition in both SAS and TW2.6 oral cancer cells. Moreover, the fruit extracts had differential effects on cell proliferation of oral cancer cells. In addition, the fruit extracts hampered cell migration and invasion of oral cancer cells, particularly in TT‐(fr) extracts. Our results indicated that TT‐(fr) extracts consistently inhibited autophagic flux, cell growth and metastatic characteristics of oral cancer cells, suggesting TT‐(fr) might contain function ingredient to suppress oral cancer cells.

中文翻译：

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rest藜果实提取物抑制自噬通量以减少口腔癌细胞的细胞增殖和转移特性

自噬升高与癌症的发展和进展高度相关。几种植物的果实提取物抑制自噬相关蛋白酶ATG4B的活性和结直肠癌细胞中的自噬活性。然而，这些植物提取物在口腔癌细胞中的作用仍不清楚。在这项研究中，我们发现提取的Tri藜果实（TT-（fr））和Xanthium strumarium水果对SAS和TW2.6口腔癌细胞均具有自噬抑制作用。而且，水果提取物对口腔癌细胞的细胞增殖具有不同的作用。此外，水果提取物阻碍了口腔癌细胞的细胞迁移和侵袭，特别是在TT-（fr）提取物中。我们的结果表明，TT-（fr）提取物始终抑制口腔癌细胞的自噬通量，细胞生长和转移特性，这表明TT-（fr）可能含有抑制口腔癌细胞的功能成分。