Kambô is a cleansing ritual involving the application of a toxin produced by the giant leaf frog (Phyllomedusa bicolor). The Kambô ritual has increasingly been adopted among cancer patients in Europe. Accumulating data indicate various adverse effects. We report another severe adverse reaction to Kambô, a systemic inflammatory response syndrome mimicking disease progression in a patient with cholangiocarcinoma. We describe a systemic reaction to Kambô, manifested as tachycardia, tachypnea, impaired liver cholestatic enzymes, and enlargement of lymphadenopathy mimicking disease progression. The clinical features and onset of symptoms, the rapid reaction, and the lack of other identified causes make the diagnosis of Kambô-induced SIRS highly probable. This case report calls for future studies examining standard oncological care such as chemotherapy, radiotherapy, and immunotherapy in conjunction with alternative therapy. Additionally, greater awareness and physician education should be promoted, encouraging inquiry of oncology patients’ administration of alternative, complementary, and integrative medicine.

Kambô 是一种清洁仪式，涉及使用由巨型叶蛙 ( Phyllomedusa bicolor)产生的毒素）。Kambô 仪式在欧洲的癌症患者中越来越多地被采用。积累的数据表明各种不利影响。我们报告了对 Kambô 的另一种严重不良反应，这是一种模仿胆管癌患者疾病进展的全身炎症反应综合征。我们描述了对 Kambô 的全身反应，表现为心动过速、呼吸急促、肝胆汁淤积酶受损和模仿疾病进展的淋巴结肿大。临床特征和症状发作、快速反应以及缺乏其他确定的原因使得诊断为 Kambô 诱导的 SIRS 的可能性很高。本病例报告呼吁未来研究检查标准肿瘤护理，如化疗、放疗和免疫治疗与替代疗法相结合。此外，