Purpose To assess the relationship of demographics, clinical characteristics and structural optical coherence tomography (OCT) findings to disease recurrence in a cohort of patients with newly diagnosed myopic choroidal neovascularisation (CNV) Methods In this retrospective, longitudinal study, a total of 64 participants (64 eyes) with successfully treated myopic CNV had obtained resolution of exudation after treatment (study baseline) and with 3 years of regular follow-ups. Several baseline OCT qualitative features and quantitative measurements were assessed at baseline and included in the analysis. Main outcome measures included incidence of disease recurrence and HR for demographics, clinical characteristics and OCT risk factors. Results At month 36, 40 eyes (62.5%) developed disease recurrence (active CNV). Multivariate linear regression analysis revealed that final visual acuity (dependent variable) was associated with visual acuity at the first visit after complete resolution of exudation (p<0.0001), baseline size of patchy atrophy (p=0.010), baseline subfoveal choroidal thickness (p=0.008), baseline maximum CNV height and width (p=0.011 and p=0.003) and recurrence of CNV exudation (p=0.007). The following factors were associated with an increased risk of disease recurrence: size of patchy atrophy had an HR of 1.14 (95% CI 1.01 to 1.29; p=0.036); maximum CNV width had an HR of 1.02 (95% CI 1.01 to 1.04; p<0.0001). Conclusion We identified OCT risk factors for the disease recurrence in eyes with successfully treated myopic CNV. Assuming that disease recurrence is a sight-threatening event, our findings may help in the identification of high-risk patients and eventually ameliorate their outcome. Data are available upon reasonable request. Data are available upon request to the corresponding author.

中文翻译：

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成功治疗近视脉络膜新生血管的眼部疾病复发的 3 年 OCT 预测因素

目的 在新诊断的近视脉络膜新生血管 (CNV) 患者队列中评估人口统计学、临床特征和结构光学相干断层扫描 (OCT) 结果与疾病复发的关系。方法在这项回顾性纵向研究中，共有 64 名参与者 (成功治疗近视 CNV 的 64 只眼在治疗后（研究基线）和 3 年的定期随访中获得了渗出消退。在基线时评估了几个基线 OCT 定性特征和定量测量值并包含在分析中。主要结果测量包括疾病复发率和人口统计学、临床特征和 OCT 危险因素的 HR。结果在第 36 个月，40 只眼 (62.5%) 出现疾病复发（活动性 CNV）。多变量线性回归分析显示，最终视力（因变量）与渗出完全消退后首次就诊时的视力（p<0.0001）、斑块萎缩基线大小（p=0.010）、中心凹下脉络膜基线厚度（p =0.008)、基线最大 CNV 高度和宽度 (p=0.011 和 p=0.003) 和 CNV 渗出复发 (p=0.007)。以下因素与疾病复发风险增加相关：斑片萎缩大小的 HR 为 1.14（95% CI 1.01 至 1.29；p=0.036）；最大 CNV 宽度的 HR 为 1.02（95% CI 1.01 至 1.04；p<0.0001）。结论 我们确定了成功治疗近视 CNV 眼睛疾病复发的 OCT 危险因素。假设疾病复发是威胁视力的事件，我们的研究结果可能有助于识别高危患者并最终改善他们的结果。可根据合理要求提供数据。数据可向通讯作者索取。