Introduction: Recently, “low-grade appendiceal mucinous neoplasms” (LAMNs) have been proposed as one subtype of appendiceal mucinous neoplasms, characterized by a villous or flat proliferation of mucinous epithelium with low-grade cytologic atypia. The aim of this study was to clarify the clinicopathological characteristics of LAMN. Methods: In this multi-institutional cohort study, we retrospectively analyzed the clinicopathological characteristics in appendiceal neoplasms patients who underwent treatment from 2000 to 2017. Results: In total, 922 patients were enrolled, with 279 (30.3%) cases of LAMN, and 93 (10.1%) cases of non-LAMN disease. In comparison with patients with non-LAMN disease, those with LAMN had significantly lower levels of CA19-9 (p = 0.045), a lower frequency of T4 tumors (p #x3c; 0.0001), a lower frequency of lymph node metastasis (p #x3c; 0.0001), and a lower frequency of distant metastasis (p #x3c; 0.0001). Survival analysis revealed that patients with LAMN had a significantly better prognosis than did those with non-LAMN disease (p #x3c; 0.001). Among the patients with distant metastasis, those with LAMN had a significantly better prognosis than did those with non-LAMN disease (p = 0.0020), but among the patients without distant metastasis, the difference between the 2 groups was not significant (p = 0.26). However, among patients who underwent complete resection, the difference in prognosis between the 2 groups was not significant (p = 0.10). Conclusions: A multicenter retrospective study revealed that the clinicopathological characteristics of LAMN was different from those of non-LAMN.
Dig Surg

中文翻译：

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阑尾低级别黏液性肿瘤的临床病理特征

简介：最近，“低级别阑尾黏液性肿瘤”（LAMNs）被认为是阑尾黏液性肿瘤的一种亚型，其特征是黏液上皮的绒毛状或扁平状增殖，伴有低度细胞学异型性。本研究的目的是阐明 LAMN 的临床病理特征。方法：在这项多机构队列研究中，我们回顾性分析了 2000 年至 2017 年接受治疗的阑尾肿瘤患者的临床病理特征。结果：共纳入 922 例患者，其中 279 例（30.3%）LAMN 和 93 例(10.1%) 非 LAMN 疾病病例。与非 LAMN 患者相比，LAMN 患者的 CA19-9 水平显着降低（ p= 0.045)、较低的 T4 肿瘤频率 ( p #x3c; 0.0001)、较低的淋巴结转移频率 ( p #x3c; 0.0001) 和较低的远处转移频率 ( p #x3c; 0.0001)。生存分析显示，LAMN 患者的预后明显优于非 LAMN 患者（p #x3c；0.001）。在远处转移患者中，LAMN患者预后明显优于非LAMN患者（p = 0.0020），但在无远处转移患者中，两组间差异不显着（p= 0.26）。然而，在接受完全切除的患者中，2组之间的预后差异不显着（p =0.10）。结论：一项多中心回顾性研究表明，LAMN 的临床病理特征与非 LAMN 不同。
挖掘外科