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Endocrine-disrupting chemicals and child health
Best Practice & Research Clinical Endocrinology & Metabolism ( IF 7.4 ) Pub Date : 2021-03-10 , DOI: 10.1016/j.beem.2021.101516
Wieland Kiess 1 , Gabriele Häussler 2 , Mandy Vogel 1
Affiliation  

Endocrine-disrupting chemicals (EDCs) are chemicals which are introduced into the environment by human activities. In many cases it has been proven that EDCs can cause adverse health effects in the human. EDCs are classified by their chemical structure, putative direct or indirect effects on endocrine glands and systems, may accumulate and persist in organisms and in the environment, and/or they may exert clinically observable and measurable effects. Often, EDCs may act in concert and as mixtures. Legislation to ban EDCs and protect especially pregnant women and children at young age are needed and needs to be revised and adjusted to new developments on a regular basis. Putative associations, in spite of sometimes conflicting results, have to be analyzed in in vitro model systems be it in cell biology, in vitro settings or animal studies in more detail. This chapter depicts the mainly positive albeit detrimental epidemiological findings for EDC-caused effects in the fields of growth and metabolism, neurocognitive development and sexual development and reproduction.



中文翻译:

内分泌干​​扰物与儿童健康

内分泌干​​扰化学品 (EDC) 是通过人类活动引入环境的化学品。在许多情况下,已证明 EDC 会对人类健康造成不利影响。EDCs 根据其化学结构、对内分泌腺体和系统的假定直接或间接影响进行分类,可能在生物体和环境中积累和持续存在,和/或它们可能发挥临床可观察和可测量的影响。通常,EDC 可以协同作用并作为混合物起作用。需要立法来禁止 EDC,尤其是保护年轻的孕妇和儿童,并且需要定期修订和调整以适应新的发展。尽管有时结果相互矛盾,但假定的关联必须在体外模型系统中进行分析,无论是在细胞生物学中,更详细的体外环境或动物研究。本章描述了 EDC 在生长和新陈代谢、神经认知发育以及性发育和生殖领域中引起的影响的主要积极但有害的流行病学发现。

更新日期:2021-03-10
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