The synthesis of a third generation dronic acid, zoledronic acid by the reaction of imidazol- 1-yl-acetic acid with phosphorus trichloride/phosphorous acid in diethyl carbonate (DEC) as a “green” solvent, and in DEC – methanesulfonic acid (MSA) solvent mixtures is described. The earlier not “green” and expensive MSA and sulfolane solvents may be replaced by DEC.

中文翻译：

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使用碳酸二乙酯作为溶剂组分，由咪唑-1-基乙酸和P-试剂“更环保”地合成唑来膦酸

咪唑-1-基乙酸与三氯化磷/亚磷酸在碳酸二乙酯（DEC）中作为“绿色”溶剂，以及在DEC-甲磺酸（MSA）中的反应，合成第三代醛酸唑来膦酸描述了溶剂混合物。DEC可以代替较早的，并非“绿色”且昂贵的MSA和环丁砜溶剂。