Willingness to donate hair samples is a rate-limiting step for assaying antiretroviral (ARV) concentrations in hair, an emerging technique for HIV prevention and treatment monitoring. We surveyed ethnically diverse Nigerians to determine their willingness to donate hair for biomedical research. A cross-sectional survey of people living with HIV on ARV therapy (ART) was conducted at the HIV clinic of Nigerian Institute of Medical Research, using systematic sampling. The researcher-administered questionnaire was designed to capture sociodemographic data, length of time on ART, and willingness to donate hair. Univariate analysis was performed on sociodemographic characteristics, and independent-samples t-test and chi-square tests were used for bivariate analysis. Multivariable logistic regression analysis was performed to assess factors associated with willingness to donate hair samples, with a significance level of 0.05. Of the 398 participants enrolled in the study, 258 (64.8%) were female, the average age was 40 years (±9.8), and the average time spent on ART was 7.3 years (±4.2). More than half (64.8%) of the respondents were willing to donate hair samples for biomedical research and they were 1.5 times more likely to donate hair than blood. For one-third of the participants, the anticipated benefit from the eventual research findings was the primary motivation to donate hair samples. Fear of use of hair for rituals was the most common stated reason for unwillingness to donate hair samples (21.2%). In an ethnically diverse, urban-based Nigerian study population, nearly two-thirds of the participants were willing to donate hair samples for biomedical research. These findings support the feasibility of hair sampling for future HIV clinical research conducted within Nigeria.

中文翻译：

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尼日利亚拉各斯一家门诊诊所的艾滋病毒感染者对捐赠头发和其他生物样本进行研究的接受度很高

捐赠头发样本的意愿是测定头发中抗逆转录病毒 (ARV) 浓度的限速步骤，这是一种艾滋病毒预防和治疗监测的新兴技术。我们对不同种族的尼日利亚人进行了调查，以确定他们是否愿意捐献头发用于生物医学研究。尼日利亚医学研究所艾滋病毒诊所采用系统抽样方法，对接受抗逆转录病毒疗法 (ART) 的艾滋病毒感染者进行了横断面调查。研究人员管理的问卷旨在获取社会人口统计数据、接受 ART 的时间长度以及捐献头发的意愿。对社会人口统计学特征进行单变量分析，并使用独立样本t检验和卡方检验进行双变量分析。进行多变量逻辑回归分析来评估与捐赠头发样本意愿相关的因素，显着性水平为0.05。参与该研究的 398 名参与者中，258 名（64.8%）为女性，平均年龄为 40 岁（±9.8），平均花在 ART 上的时间为 7.3 年（±4.2）。超过一半（64.8%）的受访者愿意捐献头发样本用于生物医学研究，他们捐献头发的可能性是捐献血液的1.5倍。对于三分之一的参与者来说，最终研究结果的预期收益是捐赠头发样本的主要动机。害怕在仪式中使用头发是不愿意捐赠头发样本的最常见原因（21.2%）。在一个种族多元化、以城市为基础的尼日利亚研究人群中，近三分之二的参与者愿意捐赠头发样本用于生物医学研究。这些发现支持了尼日利亚未来进行的艾滋病毒临床研究中毛发取样的可行性。