Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

中文翻译：

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是什么让（羟基）氯喹对 COVID-19 无效：来自细胞生物学的见解

由于氯喹 (CQ) 和羟氯喹 (HCQ) 可以抑制 SARS-CoV-2 在培养细胞中的侵袭和增殖，因此重新利用这些抗疟药物被认为是治疗和预防 COVID-19 的有希望的策略。然而，尽管初步研究结果令人鼓舞，但许多临床试验显示 CQ 和 HCQ 对 COVID-19 的治疗和预防均无显着益处。在这里，我们旨在通过检查 CQ 和 HCQ 在预防 SARS-CoV-2 感染中的细胞工作机制来回答为什么这些药物对这种疾病无效的问题。