ABSTRACT

Aims: The Talking With Voices pilot trial assesses feasibility and acceptability of a novel dialogical intervention to ameliorate distress associated with auditory hallucinations. The results will inform a definitive randomised trial to assess clinical and cost-effectiveness of the intervention.

Method: The trial is single-site with a single-blind (rater) design in which adult participants with a diagnosis of schizophrenia-spectrum disorder are randomised to receive either treatment as usual (TAU), or TAU plus up to 26 sessions of Talking With Voices therapy over six months. Participants are assessed at baseline and again at six-month follow-up. The primary outcomes are quantitative and qualitative assessments of feasibility and acceptability amongst patients and healthcare staff. Secondary outcomes will involve clinical measures, including targeted instruments for voice hearing, dissociation, and emotional distress.

Results: Recruitment figures and baseline characteristics of the sample are reported (N=50).

Conclusions: The Talking With Voices pilot trial aims to extend the evidence-base for interventions which use techniques such as dialogue, formulation and trauma-informed working to improve relationships between hearer and voice. Current findings demonstrate that recruitment and treatment allocation targets were met. If shown to be acceptable, the intervention may provide new therapeutic options for voice hearers with a diagnosis of psychosis.

摘要

目标：“与声音交谈”试点试验评估了一种新颖的对话干预措施的可行性和可接受性，以改善与幻听相关的痛苦。结果将为最终的随机试验提供信息，以评估干预的临床和成本效益。

方法：该试验是单点单盲（评估者）设计，其中诊断为精神分裂症谱系障碍的成年参与者随机接受常规治疗 (TAU) 或 TAU 加最多 26 次 Talking使用 Voices 治疗超过六个月。参与者在基线时进行评估，并在六个月的随访时再次进行评估。主要结果是对患者和医护人员的可行性和可接受性进行定量和定性评估。次要结果将涉及临床措施，包括用于声音听力、分离和情绪困扰的目标仪器。

结果：报告了样本的招募数据和基线特征（N=50）。

结论：Talking With Voices 试点试验旨在扩展干预措施的证据基础，这些干预措施使用对话、制定和创伤知情工作等技术来改善听者与声音之间的关系。目前的调查结果表明，招募和治疗分配目标得到了满足。如果被证明是可以接受的，干预可能会为患有精神病的声音聆听者提供新的治疗选择。