ABSTRACT

This study is to explore the function of working memory (WM) and autobiographical memory (AM) in patients with chronic pain. Totally, 331 patients with chronic pain and 333 healthy controls were recruited. These subjects were subjected to assessment with Pain Assessment Protocol (PAP), Visual Analogue Scale (VAS), Working Memory Index (WMI) and Autobiographical Memory Test (AMT). Patients with chronic pain scored significantly lower in WMI and higher in overgeneral autobiographical memory (OGM) of AMT. Chronic pain was significantly negatively related with WM and positively related with OGM. The structural equation model indicated that WM mediated the relationship of chronic pain and OGM. These findings suggest that WM and AM are impaired in the patients with chronic pain,,chronic pain is closely related with OGM, and WM acts an important mediating role between chronic pain and OGM.

摘要

本研究旨在探讨慢性疼痛患者的工作记忆（WM）和自传体记忆（AM）的功能。共招募了331名慢性疼痛患者和333名健康对照者。这些受试者接受了疼痛评估协议 (PAP)、视觉模拟量表 (VAS)、工作记忆指数 (WMI) 和自传体记忆测试 (AMT) 的评估。慢性疼痛患者的 WMI 得分显着降低，而 AMT 的总体自传记忆 (OGM) 得分更高。慢性疼痛与 WM 显着负相关，与 OGM 正相关。结构方程模型表明 WM 介导了慢性疼痛和 OGM 的关系。这些发现提示慢性疼痛患者WM和AM受损，慢性疼痛与OGM密切相关，