Abstract

This study is aimed at comparing the bio-efficacy of different inorganic and organic Se compounds. Three broiler experiments (Exp1 = Ross PM3; Exp2 = Ross 308; and Exp3 = Ross 308) were performed, on the basis of Se tissue accretion, to define the bio-efficacy of Se sources. Birds were fed a control diet (negative control [NC]; no supplemental Se) and, depending on the study, the NC was supplemented with sodium selenite (SS), Se-yeast (35%, 56%, 65% or 72% of Se as selenomethionine (SeMet); SY35, SY56, SY65 and SY72), pure forms of selenocysteine (SeCys) (methylselenocysteine [MSeCys]; L-selenocystine [L-SeCys]), or pure form of organic Se (L-selenomethionine, L-SeMet or hydroxy-selenomethionine, OH-SeMet) at 0.3 mg Se/kg. In Exp 2, an additional treatment of SY65 + L-SeCys was also fed, with both sources added at 0.3 mg Se/kg. In Exp3, L-SeMet and OH-SeMet, were supplemented at 0.15, 0.30, 0.45 and 0.60 mg Se/kg. The results of Exp 1 (mg Se/kg muscle DM) were: NC, 0.56; SS, 0.73; MSeCys, 0.68; L-SeCys, 0.70; SY65, 1.52; OH-SeMet, 1.85 (p < .001); Exp 2 were: NC, 0.34; SS, 0.52; SY35, 0.84; SY65, 1.18; SY65 + L-SeCys, 1.22; OH-SeMet: 1.33 (p < .001); Exp 3 were: NC, 0.10; SS, 0.31; SY56, 0.88; SY72, 1.03; L-SeMet, 1.33; OH-SeMet, 1.33 (p < .01). The results of these three studies demonstrate that the bio-efficacy of organic Se supplements for chickens depends upon the proportion of SeMet, while dietary SeCys sources showed similar bio-efficacy as SS. Moreover, these data showed the high bio-efficacy of the pure form of organic Se and the bioequivalence between L-SeMet and OH-SeMet.

• Highlights

• Updated knowledge on the bioavailability of different Se compounds in broiler.

• Direct L-selenomethionine and hydroxy-selenomethionine comparison.

摘要

这项研究旨在比较不同无机和有机硒化合物的生物功效。在硒组织增加的基础上，进行了三个肉鸡实验（实验1 = Ross PM3；实验2 = Ross 308；实验3 = Ross 308），以定义硒源的生物功效。给鸟类喂食对照饮食（阴性对照[NC]；不补充Se），根据研究，NC补充亚硒酸钠（SS），硒酵母（35％，56％，65％或72％）作为硒代蛋氨酸（SeMet）； SY35，SY56，SY65和SY72的硒，纯形式的硒代半胱氨酸（SeCys）（甲基硒代半胱氨酸[MSeCys]； L-硒代半胱氨酸[L-SeCys]）或​​有机硒（L-硒代蛋氨酸）的纯净形式（L-SeMet或羟基硒代蛋氨酸，OH-SeMet）的浓度为0.3 mg Se / kg。在实验2中，还添加了SY65 + L-SeCys的另一种处理方法，两种来源的添加量均为0.3 mg Se / kg。在Exp3中，L-SeMet和OH-SeMet的添加量分别为0.15、0.30、0.45和0.60 mg Se / kg。Exp 1（mg Se / kg肌肉DM）的结果为：NC，0.56; SS，0.73；MSeCys，0.68； m / z。L-半胱氨酸，0.70; SY65，1.52。OH-SeMet，1.85（p  <.001）；实验2为：NC，0.34；SS，0.52；SY35，0.84； MS：35。SY65，1.18；SY65 + L-SeCys，1.22; OH-SeMet：1.33（p  ＜.001）；m / z（MH +）。实验3为：NC，0.10；SS，0.31；SY56，0.88; SY72，1.03； Sn，1.03。L-SeMet，1.33。OH-SeMet，1.33（p  ＜.01）。这三项研究的结果表明，有机硒补充剂对鸡的生物功效取决于SeMet的比例，而膳食中的SeCys来源显示出与SS相似的生物功效。此外，这些数据表明，有机硒的纯形式具有很高的生物功效，L-SeMet和OH-SeMet之间具有生物等效性。

• 强调

• 有关肉鸡中不同硒化合物生物利用度的最新知识。

• 直接L-硒代蛋氨酸和羟基硒代蛋氨酸的比较。