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A pilot study comparing the pharmacokinetics of injectable cyanocobalamin and hydroxocobalamin associated with a trace mineral injection in cattle
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2021-03-08 , DOI: 10.1111/jvp.12967
Paula A Gonzalez-Rivas 1, 2 , Michael Chambers 3 , Jerry Liu 1
Affiliation  

Injectable vitamin B12 (cobalamin) is traditionally used to prevent or treat vitamin B12 deficiencies in ruminants. Sheep and human studies have demonstrated the superiority of a single dose of hydroxocobalamin (OHB12) over cyanocobalamin (CNB12) in maintaining high levels of cobalamin in plasma and liver. However, limited data are available for cattle. The purpose of this study was to compare the pharmacokinetics of two forms of cobalamin—OHB12 and CNB12—as a single subcutaneous injection of 28 µg/kg BW at the same time of a trace mineral injection in six non-cobalt/B12-deficient Holstein-Friesian steers. Plasma and liver samples were obtained to determine cobalamin concentration after treatment. Cyanocobalamin had lower retention in plasma and liver than OHB12 (p < .05). Cobalamin levels peaked in plasma by 8 h after treatment in both groups. However, OHB12 reached a higher peak compared to CNB12. Levels of cobalamin in plasma dropped closer to baseline levels 24 h after CNB12 treatment while OHB12 maintained higher concentrations. Hydroxocobalamin increased significantly hepatic concentration of cobalamin 28 days after treatment, while CNB12 did not increase liver levels relative to pre-treatment (p < .05). These results confirm that a single subcutaneous OHB12 injection increases the level of cobalamin in the blood in the first 24 hours, and this increase is maintained in the liver for at least 28 days.

中文翻译:

一项初步研究比较了注射用氰钴胺素和羟钴胺素在牛体内注射微量矿物质的药代动力学

注射用维生素 B 12(钴胺素)传统上用于预防或治疗反刍动物的维生素 B 12缺乏症。绵羊和人体研究表明,在维持血浆和肝脏中高水平的钴胺素方面,单剂量的羟钴胺素 (OHB12) 优于氰钴胺素 (CNB12)。然而,关于牛的可用数据有限。本研究的目的是比较两种形式的钴胺素(OHB12 和 CNB12)的药代动力学,在注射六种非钴/B 12微量矿物质的同时,单次皮下注射 28 µg/kg BW- 缺乏荷斯坦-弗里斯兰阉牛。获得血浆和肝脏样品以确定治疗后的钴胺素浓度。氰钴胺素在血浆和肝脏中的保留率低于 OHB12(p < .05)。两组治疗后8小时血浆中钴胺素水平达到峰值。然而,与 CNB12 相比,OHB12 达到了更高的峰值。CNB12 治疗后 24 小时,血浆中钴胺素水平下降至接近基线水平,而 OHB12 保持较高浓度。羟钴胺素在治疗后 28 天显着增加肝脏钴胺素浓度,而 CNB12 相对于治疗前没有增加肝脏水平 (p < .05)。这些结果证实,单次皮下注射 OHB12 会在最初的 24 小时内增加血液中钴胺素的水平,并且这种增加会在肝脏中维持至少 28 天。
更新日期:2021-03-08
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