Mechanotransduction is the ability of a cell to sense mechanical cues from its microenvironment and convert them into biochemical signals to elicit adaptive transcriptional and other cellular responses. Here, we describe recent advances in the field of mechanical regulation of transcription, highlight mechanical regulation of the epigenome as a key novel aspect of mechanotransduction, and describe recent technological advances that could further elucidate the link between mechanical stimuli and gene expression. In this review, we emphasize the importance of mechanotransduction as one of the governing principles of cancer progression, underscoring the need to conduct further studies of the molecular mechanisms involved in sensing mechanical cues and coordinating transcriptional responses.

机械转导是细胞感知微环境中的机械信号并将其转化为生化信号以引发适应性转录和其他细胞反应的能力。在这里，我们描述了转录机械调控领域的最新进展，强调表观基因组的机械调控作为机械转导的一个关键新方面，并描述了可以进一步阐明机械刺激和基因表达之间联系的最新技术进展。在这篇综述中，我们强调机械转导作为癌症进展的控制原则之一的重要性，强调需要对涉及感知机械线索和协调转录反应的分子机制进行进一步研究。