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Metam sodium exposure during pregnancy and lactation in mice caused behavioral abnormalities and oxidative stress in offspring
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2021-03-09 , DOI: 10.1016/j.etap.2021.103630
Nour-Eddine Kaikai 1 , Saadia Ba-M'hamed 2 , Abderrazzak Ghanima 3 , Mohamed Bennis 2
Affiliation  

Metam sodium (MS) is a widespread biocide with a broad-spectrum activity. Here, we addressed the behavioral impact of MS by exposing female mice to 50, 100 and 150 mg/kg of MS during both pregnancy and lactation, and evaluated the oxidative stress as a potential mechanism of MS-induced neurotoxicity. The results showed that MS affected fertility and reproduction parameters as well as some aspects of maternal behavior, especially at high doses. In offspring, MS caused a significant delay in the ontogeny of sensorimotor functions. In addition, treated mice exhibited during adulthood an increase of anxiety-like, depression-like behaviors as well as learning and memory impairment. These alterations were accompanied by an increase of the superoxide dismutase activity, and a significant decreased catalase and malondialdehyde activities in specific brain areas. The present work revealed that early exposure to MS induced sensorimotor and behavioral impairments in offspring likely associated with onset of oxidative stress.



中文翻译:

小鼠孕期和哺乳期Metam钠暴露导致后代行为异常和氧化应激

Metam 钠 (MS) 是一种广泛使用的具有广谱活性的杀菌剂。在这里,我们通过在怀孕和哺乳期间将雌性小鼠暴露于 50、100 和 150 mg/kg MS 来解决 MS 的行为影响,并评估氧化应激作为 MS 诱导神经毒性的潜在机制。结果表明,MS 会影响生育能力和生殖参数以及母亲行为的某些方面,尤其是在高剂量下。在后代中,MS 导致感觉运动功能的个体发育显着延迟。此外,接受治疗的小鼠在成年期表现出类似焦虑、类似抑郁的行为以及学习和记忆障碍的增加。这些改变伴随着超氧化物歧化酶活性的增加,特定脑区的过氧化氢酶和丙二醛活性显着降低。目前的工作表明,早期暴露于 MS 会导致后代的感觉运动和行为障碍,这可能与氧化应激的发生有关。

更新日期:2021-03-16
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