Background

Cost-utility analysis uses utility indexes to assess treatment effects. Some discrepancies between different utility indexes instruments are suggested and need to be identified in health conditions not yet investigated.

Objective

To compare different utility indexes instruments in Brazilian patients with fibromyalgia and identify variables associated with these instruments.

Methods

Impact of fibromyalgia (Fibromyalgia Impact Questionnaire [FIQ]) and utility indexes (Short-Form 6 Dimensions [SF-6D], EuroQol 5 Dimensions [EQ-5D], and EuroQol - Visual Analogue Scale [EQ-VAS]) were assessed in 97 patients with fibromyalgia at baseline, 8-week (after an exercise-based intervention), and 6- and 12-month follow-up. Construct validity and responsiveness of the utility indexes instruments were compared. Multiple regression models were used to verify the variables associated with the utility indexes instruments.

Results

Construct validity analysis showed that FIQ presented moderate correlation with the SF-6D, the EQ-5D, and the EQ-VAS (r=-0.43, -0.41, -0.30, respectively, all p < .01). There was a moderate correlation between the SF-6D and the EQ-5D (r = 0.51, p < .001), moderate correlation between the SF-6D and the EQ-VAS (r = 0.41, p < .001), and no correlation between the EQ-VAS and the EQ-5D. The EQ-5D was responsive at the 8-week and 6-month follow-up, the SF-6D was responsive only at 6-month follow-up and the EQ-VAS was not responsive. The FIQ was associated with the EQ-5D and the SF-6D indexes, and symptom duration and depression with the EQ-VAS index.

Conclusion

The EQ-5D better assessed the clinical change in patients with fibromyalgia. Furthermore, impact of fibromyalgia, symptom duration, and depression seem to be associated with the utility indexes.

中文翻译：

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纤维肌痛患者不同健康状态实用工具的比较

背景

成本效用分析使用效用指数来评估治疗效果。建议了不同效用指数工具之间的一些差异，需要在尚未调查的健康状况中确定。

客观的

比较巴西纤维肌痛患者的不同效用指数仪器，并确定与这些仪器相关的变量。

方法

纤维肌痛的影响（纤维肌痛影响问卷 [FIQ]）和效用指数（Short-Form 6 Dimensions [SF-6D]、EuroQol 5 Dimensions [EQ-5D] 和 EuroQol - Visual Analogue Scale [EQ-VAS]）在97 名在基线、8 周（基于运动的干预后）以及 6 个月和 12 个月随访时患有纤维肌痛的患者。比较了效用指标工具的结构效度和响应性。多元回归模型用于验证与效用指数工具相关的变量。

结果

结构效度分析表明，FIQ 与 SF-6D、EQ-5D 和 EQ-VAS 呈中度相关（分别为 r=-0.43、-0.41、-0.30，均 p < .01）。SF-6D 和 EQ-5D 之间存在中等相关性（r = 0.51，p < .001），SF-6D 和 EQ-VAS 之间存在中等相关性（r = 0.41，p < .001），以及EQ-VAS 和 EQ-5D 之间没有相关性。EQ-5D 在 8 周和 6 个月的随访时有反应，SF-6D 仅在 6 个月的随访时有反应，EQ-VAS 无反应。FIQ 与 EQ-5D 和 SF-6D 指数相关，症状持续时间和抑郁与 EQ-VAS 指数相关。

结论

EQ-5D 更好地评估了纤维肌痛患者的临床变化。此外，纤维肌痛、症状持续时间和抑郁的影响似乎与效用指数相关。