Intensive care unit (ICU) infection management is a growing challenge, and physicians should have regularly updated antibiograms. The aim of this study was to find out the prevalence of pathogens and to determine their antibiotic susceptibility in different ICUs of an Egyptian tertiary care hospital. This retrospective record-based cross-sectional study was conducted from the first of January to the last of December 2019 with a total of 45,221 diagnostic first-isolate culture/patient obtained from different ICUs in Zagazig University Hospitals. The antibiogram construction was done according to Clinical and Laboratory Standards Institute instructions and a Web-based antibiogram at Stanford University. The positive blood isolate was the most prevalent infection site (32.37%) followed by sputum and urine isolates. Gram-negative microorganisms (74.41%) were the most common pathogens, with Klebsiella pneumoniae as the most frequently identified one with an incidence of 33.51% followed by Escherichia coli with 19.3% incidence. Antibiotic sensitivity showed that colistin is the most effective antibiotic with 96.2%, 94.7%, and 89.9% sensitivity for Klebsiella, E. coli, and Acinetobacter, respectively, while carbepenems sensitivity was extremely low, showing 19.5% and 19% imipenem and meropenem sensitivity for Klebsiella, 48% imipenem and 52.7% meropenem sensitivity for E. coli, 20.1% imipenem and 20.3% meropenem sensitivity for Acinetobacter, and 17.3% imipenem and 15.2% meropenem sensitivity for Pseudomonas aeruginosa. Fungal infection in our results represented less than 1%. Our study provides a local baseline epidemiological data which describes the extent of the ICU infections problem in this tertiary care hospital. ClinicalTrials.gov (NCT04318613)

中文翻译：

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埃及三级护理医院的重症监护室抗菌素谱

重症监护病房（ICU）感染管理是一个日益严峻的挑战，医生应定期更新抗菌素。这项研究的目的是找出病原体的流行情况，并确定其在埃及三级医院的不同ICU中的抗生素敏感性。这项基于记录的回顾性横断面研究于2019年1月1日至12月下旬进行，从Zagazig University Hospitals的不同ICU获得了总共45,221例诊断性第一分离培养物/患者。按照临床和实验室标准协会的指示以及斯坦福大学的基于网络的抗菌谱图进行抗菌谱图的构建。阳性血液分离株是最普遍的感染部位（32.37％），其次是痰和尿分离株。革兰氏阴性微生物（74。41％）是最常见的病原体，肺炎克雷伯菌是最常见的病原体，发生率为33.51％，其次是大肠杆菌，发生率为19.3％。抗生素敏感性显示，大肠菌素是最有效的抗生素，对克雷伯菌，大肠杆菌和不动杆菌的敏感性分别为96.2％，94.7％和89.9％，而碳青霉烯类药物的敏感性极低，对亚胺培南和美洛培南的敏感性分别为19.5％和19％。对克雷伯菌而言，对大肠杆菌的亚胺培南敏感性为48％，对美罗培南的敏感性为52.7％，对不动杆菌为20.1％亚胺培南和美洛培南的敏感性，对铜绿假单胞菌为17.3％亚胺培南和美罗培南的敏感性为15.2％。在我们的结果中，真菌感染占不到1％。我们的研究提供了本地基准流行病学数据，该数据描述了该三级护理医院中ICU感染问题的严重程度。ClinicalTrials.gov（NCT04318613）