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Doege-Potter syndrome: a case report
International Journal of Diabetes in Developing Countries ( IF 0.9 ) Pub Date : 2021-03-08 , DOI: 10.1007/s13410-021-00938-4
Abhishek Yadav , C. L. Nawal , Abhishek Agrawal , Aradhana Singh , Radhey Shyam Chejara

Introduction

Doege-Potter syndrome is a rare paraneoplastic syndrome presenting as hypoinsulinemic hypoglycemia due to ectopic secretion of prohormone: insulin-like growth factor-2 (IGF-2) from a solitary fibrous tumor (SFT). It is essentially a non-islet cell tumor hypoglycemia (NICTH) or in more recent terms, an ‘IGF-2oma’. In case of delay in diagnosis, tumor-induced hypoglycemia could cause hypoxic cerebral injury or death. We hereby present a case of 45 years old male who presented with hypoglycemia due to pleural SFT, which is a very rare and unique presentation.

Results

Upon biochemical and radiological investigations, Doege-Potter syndrome was diagnosed and the patient was planned for surgical resection of the tumor.

Conclusion

This case stresses upon thorough evaluation of patients presenting with non-diabetic hypoglycemia to rule out underlying malignancy.



中文翻译:

Doege-Potter综合征:一例报告

介绍

Doege-Potter综合征是一种罕见的副肿瘤综合征,由于从孤立性纤维性肿瘤(SFT)分泌异位激素:胰岛素样生长因子2(IGF-2)而异位表现为低胰岛素血症性低血糖。它本质上是一种非胰岛细胞瘤低血糖症(NICTH),或更近期而言是一种“ IGF-2oma”。如果延误诊断,肿瘤引起的低血糖症可能会导致缺氧性脑损伤或死亡。我们特此介绍一例45岁男性,由于胸膜SFT而出现低血糖,这是一种非常罕见且独特的表现。

结果

经过生化和放射学检查,诊断出Doege-Potter综合征,并计划对该患者进行手术切除。

结论

该病例强调对患有非糖尿病性低血糖的患者进行彻底评估以排除潜在的恶性肿瘤。

更新日期:2021-03-08
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