X-ray phase contrast imaging can provide improved or complementary information to traditional attenuation-based X-ray imaging, making the field a vast and rapidly evolving research subject. X-ray speckle-based imaging (SBI) is one phase-contrast imaging approach that has shown significant potential in providing both high sensitivity and high resolution while using a very simple experimental setup. With the aim of transferring such phase-contrast-based imaging techniques from synchrotron to laboratory X-ray sources, the issue of the deposited radiation dose still remains to be addressed. In this work, we experimentally and quantitatively compare the results from three different SBI phase retrieval algorithms using both phantoms and biological samples in order to infer the optimal configuration. The results obtained using a synchrotron beam suggest that the technique based on optical flow conservation achieves the most accurate retrieval from the lowest number of sample exposures. This constitutes an important step toward the possibility of transferring SBI into the clinic.

X 射线相位对比成像可以为传统的基于衰减的 X 射线成像提供改进或补充的信息，使该领域成为一个广阔且快速发展的研究课题。基于 X 射线散斑的成像 (SBI) 是一种相衬成像方法，在使用非常简单的实验装置的同时，它在提供高灵敏度和高分辨率方面显示出巨大的潜力。为了将这种基于相位对比的成像技术从同步加速器转移到实验室 X 射线源，沉积辐射剂量的问题仍有待解决。在这项工作中，我们使用模型和生物样本对三种不同 SBI 相位检索算法的结果进行了实验和定量比较，以推断最佳配置。使用同步加速器光束获得的结果表明，基于光流守恒的技术可以从最少数量的样品曝光中实现最准确的检索。这构成了将 SBI 转移到诊所的可能性的重要一步。