Soft tissue engineering has been gaining increasing interest as an approach to overcome the limitations posed by current clinical procedures such as invasiveness of the surgery, post-operative complications and volume loss. Soft tissue damage occurs either due to congenital malformation, trauma/disease or surgical resection. Through the use of autologous cells, such as mesenchymal stem cells, combined with a biomaterial acting as a support, biological substitutes can be developed. A promising pathway in terms of delivery of these engineered constructs is the use of an injectable system, able to provide a minimally invasive approach. Advances have been made in the development of biocompatible biomaterials able to induce soft tissue regeneration. The present review provides an overview of fillers used in the clinic as well as a non-exhaustive overview of all injectable systems reported for soft tissue engineering. A particular focus is placed on the benefits and drawbacks of the biomaterials and the underlying polymerisation strategy. Furthermore, focus is placed on the mechanical properties of the systems.

软组织工程作为一种方法来克服当前临床程序所带来的限制，例如手术的侵入性、术后并发症和体积损失，越来越受到人们的关注。软组织损伤是由于先天性畸形、外伤/疾病或手术切除引起的。通过使用自体细胞，如间充质干细胞，结合作为支持的生物材料，可以开发生物替代品。就这些工程构建体的传递而言，一个有希望的途径是使用可注射系统，能够提供微创方法。在开发能够诱导软组织再生的生物相容性生物材料方面取得了进展。本综述概述了临床使用的填充剂，以及报告的用于软组织工程的所有可注射系统的非详尽概述。特别关注生物材料的优点和缺点以及潜在的聚合策略。此外，重点放在系统的机械性能上。