Major depressive disorder (MDD) is a chronic affective disorder that has a strong neuroinflammatory component underpinning its etiology. Recent studies indicate that MDD is also associated with changes in the gut microbiota and that the latter is mainly modulated by diet. Microbiota-based personalized nutrition aims to provide an individual-specific diet that will yield the maximum benefit from a given diet since the gut microbiota is accounted for the variations that individuals present in response to a given food. In this review, we present and discuss 5 possible outcomes of using microbiota-based personalized nutrition. Harnessing this approach is essential to design more accurate therapies to prevent and treat MDD or to even help in drug metabolism, especially in the case of antidepressants.
Neuroimmunomodulation

中文翻译：

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抑郁症的个性化营养：对邪恶三位一体的影响

重度抑郁症 (MDD) 是一种慢性情感障碍，其病因有很强的神经炎症成分。最近的研究表明，MDD 还与肠道微生物群的变化有关，后者主要受饮食调节。基于微生物群的个性化营养旨在提供一种特定于个体的饮食，这种饮食将从给定的饮食中产生最大的益处，因为肠道微生物群被解释为个体对给定食物的反应。在这篇综述中，我们提出并讨论了使用基于微生物群的个性化营养的 5 种可能结果。利用这种方法对于设计更准确的疗法来预防和治疗 MDD 或什至帮助药物代谢至关重要，尤其是在抗抑郁药的情况下。
神经免疫调节