Abstract

Development of mapping population is a prerequisite for genetic dissection of genomic regions underlying complex traits. Nested Association Mapping (NAM) is an integrated multi-parent population approach that combines the advantages of linkage mapping and association mapping for high resolution and high-power mapping of complex traits. The NAM population is constituent of independent RIL populations derived from crossing several diverse donor parents with a common founder parent. The first NAM population was developed in maize and later on in several crops like barley, sorghum, wheat, rice, soybean, etc. This review provides an overview of NAM population development, its features, advantages over the other mapping populations, availability of high density genotyping platforms, key considerations for their development, applications and future prospects. We propose that the recent high-throughput analytical tools including high-end genotyping will accelerate utilization of NAM population for prediction of genomic estimated breeding value and genomic assisted selection in crop improvement program.

摘要

发展作图种群是对复杂性状基础的基因组区域进行遗传解剖的前提。嵌套关联映射（NAM）是一种集成的多父母人口方法，结合了链接映射和关联映射的优点，可以实现复杂特征的高分辨率和高能级映射。NAM人口是独立的RIL人口的组成部分，这些人口是通过将几个不同的供体父母与一个共同的创始父母杂交而来的。第一个NAM种群是在玉米中发展的，后来又在大麦，高粱，小麦，水稻，大豆等几种作物中发展。该综述概述了NAM种群的发展，特征，相对于其他作图种群的优势，高可用性密度基因分型平台，其开发的主要考虑因素，应用和未来前景。我们建议，包括高端基因分型在内的最新高通量分析工具将加速利用NAM种群预测基因组估计育种价值和作物改良计划中的基因组辅助选择。