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Molecular interactions and their predictive roles in cell pole determination in bacteria
Critical Reviews in Microbiology ( IF 6.5 ) Pub Date : 2021-01-11 , DOI: 10.1080/1040841x.2020.1857686
Reema Chaudhary 1, 2 , Shruti Mishra 1, 2 , Swathi Kota 1, 2 , Hari Misra 1, 2
Affiliation  

Abstract

Bacterial cell cycle is divided into well-coordinated phases; chromosome duplication and segregation, cell elongation, septum formation, and cytokinesis. The temporal separation of these phases depends upon the growth rates and doubling time in different bacteria. The entire process of cell division starts with the assembly of divisome complex at mid-cell position followed by constriction of the cell wall and septum formation. In the mapping of mid-cell position for septum formation, the gradient of oscillating Min proteins across the poles plays a pivotal role in several bacteria genus. The cues in the cell that defines the poles and plane of cell division are not fully characterized in cocci. Recent studies have shed some lights on molecular interactions at the poles and the underlying mechanisms involved in pole determination in non-cocci. In this review, we have brought forth recent findings on these aspects together, which would suggest a model to explain the mechanisms of pole determination in rod shaped bacteria and could be extrapolated as a working model in cocci.



中文翻译:

分子相互作用及其在细菌细胞极确定中的预测作用

摘要

细菌细胞周期分为协调良好的阶段。染色体复制和分离,细胞伸长,隔膜形成和胞质分裂。这些阶段的时间间隔取决于不同细菌的生长速率和倍增时间。细胞分裂的整个过程始于在细胞中部位置组装抗体复合体,然后收缩细胞壁和隔膜形成。在间隔形成中部细胞位置的映射中,跨极的振荡Min蛋白的梯度在几种细菌属中起着关键作用。在球菌中,定义细胞分裂极点和平面的细胞线索并未得到充分表征。最近的研究揭示了两极之间的分子相互作用以及非球菌中极点确定所涉及的潜在机制。

更新日期:2021-03-07
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