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A review on Arthrobacter sp. lipase: A versatile biocatalyst for the kinetic resolution to access enantiomerically pure/enriched compounds
Chirality ( IF 2 ) Pub Date : 2021-03-06 , DOI: 10.1002/chir.23304
Pankaj Gupta 1 , Asha Chaubey 2 , Neha Mahajan 1 , Naveen Anand 3
Affiliation  

Over the last few years, there has been a dramatic increase in the number of reports related to Arthrobacter sp. lipase (ABL:MTCC No. 5125) catalyzed kinetic resolution performed in biphasic media. A strain displaying esterase/lipase activity and designated as ABL was isolated, during the course of a screening program at Indian Institute of Integrative Medicine, Jammu. Considerable research has shown that reactions catalyzed by ABL are more selective than many commercial lipases. Since new applications of this lipase are emerging, there is a great need to provide all the relevant information exclusively. This review article is an attempt to cover all the relevant reports based on isolation, purification, immobilization, and application of ABL in the biopharmaceutical sector.

中文翻译:

节杆菌属的综述。脂肪酶:一种用于动力学拆分的多功能生物催化剂,以获取对映异构纯/富集化合物

在过去几年中,与节杆菌属相关的报告数量急剧增加。脂肪酶 (ABL:MTCC No. 5125) 催化在双相介质中进行动力学拆分。在查谟印度中西医结合研究所的筛选计划过程中,分离出一种显示酯酶/脂肪酶活性并命名为 ABL 的菌株。大量研究表明,ABL 催化的反应比许多商业脂肪酶更具选择性。由于这种脂肪酶的新应用正在出现,因此非常需要专门提供所有相关信息。这篇综述文章试图涵盖基于 ABL 在生物制药领域的分离、纯化、固定和应用的所有相关报告。
更新日期:2021-04-08
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