Background: Reliable exposure control measures are needed to avoid occupational exposures from hazardous drugs. However, there is little information on blister packages concerning exposure. We investigated the contamination and exposure control methods of lenalidomide. Materials and Methods: Nine facilities involved with the RevMate program (the Japanese REMS program) participated in this study. Blister packages (10 capsules/ sheet, no cuts) were collected from each institution after the administration of 5-mg Revlimid capsules. Additionally, the safety performance of different gloves was tested. Results: A total of 18 samples were analyzed and the results revealed that all samples were contaminated with lenalidomide. Our questionnaire revealed that all pharmacists handled the blister packages with their bare hands when they were checking the remaining capsules of lenalidomide. We analyzed gloves made from four different materials (nitrile, polyvinyl chloride, latex, and polyethylene) and found no permeability in any glove type. Conclusion: We conclude that the spent blister package is a potential source of exposure to lenalidomide. All medical staff and caregivers should wear gloves when they handle lenalidomide.

背景：需要可靠的暴露控制措施来避免危险药物的职业暴露。然而，关于泡罩包装的暴露信息很少。我们调查了来那度胺的污染和暴露控制方法。材料和方法：涉及 RevMate 计划（日本 REMS 计划）的九个设施参与了本研究。在给予 5-mg Revlimid 胶囊后，从每个机构收集泡罩包装（10 粒/片，无切口）。此外，还测试了不同手套的安全性能。结果：共分析了 18 个样本，结果显示所有样本都被来那度胺污染。我们的调查问卷显示，所有药剂师在检查剩余的来那度胺胶囊时，都是徒手处理泡罩包装的。我们分析了由四种不同材料（丁腈、聚氯乙烯、乳胶和聚乙烯）制成的手套，发现任何类型的手套都没有渗透性。结论：我们得出结论，用过的泡罩包装是来那度胺暴露的潜在来源。所有医务人员和护理人员在处理来那度胺时都应戴手套。