Bacterial sporulation is a conserved process utilized by members of Bacillus genus and Clostridium in response to stress such as nutrient or temperature. Sporulation initiation is triggered by stress signals perceived by bacterial cell that leads to shutdown of metabolic pathways of bacterial cells. The mechanism of sporulation involves a complex network that is regulated at various checkpoints to form the viable bacterial spore. Engulfment is one such check point that drives the required cellular rearrangement necessary for the spore assembly and is mediated by bacterial proteolytic machinery that involves association of various Clp ATPases and ClpP protease. The present study highlights the importance of degradation of an anti-sigma factor F, SpoIIAB by ClpCP proteolytic machinery playing a crucial role in culmination of engulfment process during the sporulation in Bacillus anthracis.

细菌孢子形成是芽孢杆菌属和梭菌属成员在应对营养或温度等压力时使用的保守过程。孢子形成的起始是由细菌细胞感知的压力信号触发的，导致细菌细胞代谢途径的关闭。孢子形成的机制涉及一个复杂的网络，该网络在各个检查点受到调节以形成有活力的细菌孢子。吞噬是一个这样的检查点，它驱动孢子组装所需的所需细胞重排，并由涉及各种 Clp ATP 酶和 ClpP 蛋白酶结合的细菌蛋白水解机制介导。本研究强调了抗西格玛因子 F 降解的重要性，炭疽杆菌。