In recent conflicts, most injuries to the limbs are due to blasts resulting in a large number of lower limb amputations. These lead to heterotopic ossification (HO), phantom limb pain (PLP), and functional deficit. The mechanism of blast loading produces a combined fracture and amputation. Therefore, to study these conditions, in vivo models that replicate this combined effect are required. The aim of this study is to develop a preclinical model of blast-induced lower limb amputation.

中文翻译：

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啮齿动物高能爆炸伤害模型的开发，用于调查与创伤性截肢相关的疾病。

在最近的冲突中，对肢体的大多数伤害是由于爆炸造成的，导致大量下肢截肢。这些会导致异位骨化（HO），幻肢痛（PLP）和功能障碍。爆炸载荷的机理产生了断裂和截肢的结合。因此，为了研究这些条件，需要复制这种联合作用的体内模型。这项研究的目的是建立爆炸诱导的下肢截肢的临床前模型。