Two bicyclic peptides, nyuzenamides A (1) and B (2), were discovered from Streptomyces isolated from suspended matter in deep sea water collected in the Sea of Japan. Their structures were determined through nuclear magnetic resonance and mass spectrometry analyses in combination with X-ray crystallography and the chiral-phase gas chromatography–mass spectrometry method to comprise ten amino acid residues containing four unusual amino acids along with aromatic acyl units. Both compounds displayed antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells.

中文翻译：

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Nyuzenamides A 和 B：来自海洋来源的链霉菌属的具有抗真菌和细胞毒性活性的双环肽。

两种双环肽，nyuzenamides A ( 1 ) 和 B ( 2 )，是从从日本海收集的深海水中的悬浮物分离的链霉菌中发现的。它们的结构是通过核磁共振和质谱分析结合 X 射线晶体学和手性相气相色谱-质谱法确定的，由十个氨基酸残基组成，其中包含四个不寻常的氨基酸以及芳香酰基单元。两种化合物均显示出对病原真菌的抗真菌活性和对 P388 鼠白血病细胞的细胞毒性。