Nephropathy is a common under-recognised complication of sickle cell disease (SCD) and one of the main factors of poor prognosis in these patients. The association between nephrotic syndrome and SCD in children is rare. Strategies for sickle cell nephropathy prevention are still poorly established. Blood pressure control as well as monitoring of microalbuminuria and renal function are mandatory. The use of antiproteinuric drugs, such as anti-ACE inhibitors (ACEis) and hydroxyurea, should be considered in early stages. Here, we report a case of a female adolescent with SCD and inaugural nephrotic syndrome who, after an initial treatment failure with corticotherapy, had a remarkable recovery after treatment with hydroxyurea and ACEis.

中文翻译：

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肾病综合征对镰状细胞病：羟基脲的影响

肾病是镰状细胞病 (SCD) 常见的未被充分认识的并发症，也是这些患者预后不良的主要因素之一。儿童肾病综合征与 SCD 之间的关联很少见。镰状细胞肾病的预防策略仍不完善。血压控制以及微量白蛋白尿和肾功能的监测是强制性的。应在早期考虑使用抗蛋白尿药物，例如抗 ACE 抑制剂 (ACEis) 和羟基脲。在这里，我们报告了一例患有 SCD 和初发性肾病综合征的女性青少年，她在皮质疗法的初始治疗失败后，在用羟基脲和 ACEis 治疗后有了显着的恢复。