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The Efficacy of Percutaneous Patent Foramen Ovale Closure on Migraine: a Meta-Analysis of Randomized Controlled Trials and Observational Studies
BioMed Research International ( IF 3.246 ) Pub Date : 2021-03-05 , DOI: 10.1155/2021/6643266 Quan-Quan Zhang 1 , Jia-Jie Lu 1 , Man-Yun Yan 1 , Xiao-Wei Hu 1 , Yi-Ren Qin 1 , Da-Peng Wang 1 , Jian-Hua Jiang 1 , Qi Fang 1 , Hong-Ru Zhao 1
BioMed Research International ( IF 3.246 ) Pub Date : 2021-03-05 , DOI: 10.1155/2021/6643266 Quan-Quan Zhang 1 , Jia-Jie Lu 1 , Man-Yun Yan 1 , Xiao-Wei Hu 1 , Yi-Ren Qin 1 , Da-Peng Wang 1 , Jian-Hua Jiang 1 , Qi Fang 1 , Hong-Ru Zhao 1
Affiliation
Objectives. Whether patent foramen ovale (PFO) closure is effective on migraine is controversial. This article was aimed at assessing the efficacy of PFO closure on migraine based on randomized controlled trials (RCTs) and observational studies. Methods. We searched PubMed, Embase, and Cochrane databases up to October 2020 evaluating PFO closure versus control in patients with migraine, then conducted a meta-analysis of all RCTs and observational studies, respectively. The main outcomes were (1) respond rate: complete cessation of migraine; (2) reduction in the frequency of migraine attacks per month; and (3) reduction in migraine days per month. Results. Seven studies (3 RCTs and 4 observational studies), containing 887 migraine patients, were identified. (1) The respond rate of PFO closure on migraine was significantly higher than control group both in RCT subgroup and observational studies subgroup (OR 3.86, 95% CI 1.35-11.04, in RCTs; OR 8.28, 95% CI 2.31-29.67, in observational studies). (2) Reduction in frequency of migraine attacks was higher in PFO closure group compared with control group in the RCT subgroup analysis (, 95% CI 0.23-0.90, ). (3) Reduction in migraine days was also higher in PFO closure group compared with control group in the RCT subgroup analysis (, 95% CI 0.35-2.31, ). Conclusions. PFO closure might be suitable for migraine patients, especially for migraine with aura, by cessation of migraine headaches or reducing migraine attacks and migraine days.
中文翻译:
经皮卵圆孔未闭闭合对偏头痛的疗效:随机对照试验和观察性研究的荟萃分析
目标。卵圆孔未闭 (PFO) 闭合是否对偏头痛有效存在争议。本文旨在根据随机对照试验 (RCT) 和观察性研究评估 PFO 闭合对偏头痛的疗效。方法。我们检索了截至 2020 年 10 月的 PubMed、Embase 和 Cochrane 数据库,评估偏头痛患者的 PFO 闭合与对照,然后分别对所有 RCT 和观察性研究进行了荟萃分析。主要结果是(1)反应率:偏头痛完全停止;(2) 减少每月偏头痛发作的频率;(3) 每月偏头痛天数减少。结果. 确定了包含 887 名偏头痛患者的七项研究(3 项 RCT 和 4 项观察性研究)。(1) RCT亚组和观察性研究亚组PFO闭合对偏头痛的反应率均显着高于对照组(OR 3.86, 95% CI 1.35-11.04,在随机对照试验中;或 8.28, 95% CI 2.31-29.67,在观察性研究中)。(2) 在 RCT 亚组分析中,与对照组相比,PFO 闭合组偏头痛发作频率的降低更高(, 95% CI 0.23-0.90,)。(3)在 RCT 亚组分析中,与对照组相比,PFO 闭合组的偏头痛天数减少也更高(, 95% CI 0.35-2.31,)。 结论。通过停止偏头痛或减少偏头痛发作和偏头痛天数,PFO 闭合可能适用于偏头痛患者,尤其是有先兆偏头痛的患者。
更新日期:2021-03-05
中文翻译:
经皮卵圆孔未闭闭合对偏头痛的疗效:随机对照试验和观察性研究的荟萃分析
目标。卵圆孔未闭 (PFO) 闭合是否对偏头痛有效存在争议。本文旨在根据随机对照试验 (RCT) 和观察性研究评估 PFO 闭合对偏头痛的疗效。方法。我们检索了截至 2020 年 10 月的 PubMed、Embase 和 Cochrane 数据库,评估偏头痛患者的 PFO 闭合与对照,然后分别对所有 RCT 和观察性研究进行了荟萃分析。主要结果是(1)反应率:偏头痛完全停止;(2) 减少每月偏头痛发作的频率;(3) 每月偏头痛天数减少。结果. 确定了包含 887 名偏头痛患者的七项研究(3 项 RCT 和 4 项观察性研究)。(1) RCT亚组和观察性研究亚组PFO闭合对偏头痛的反应率均显着高于对照组(OR 3.86, 95% CI 1.35-11.04,在随机对照试验中;或 8.28, 95% CI 2.31-29.67,在观察性研究中)。(2) 在 RCT 亚组分析中,与对照组相比,PFO 闭合组偏头痛发作频率的降低更高(, 95% CI 0.23-0.90,)。(3)在 RCT 亚组分析中,与对照组相比,PFO 闭合组的偏头痛天数减少也更高(, 95% CI 0.35-2.31,)。 结论。通过停止偏头痛或减少偏头痛发作和偏头痛天数,PFO 闭合可能适用于偏头痛患者,尤其是有先兆偏头痛的患者。