Background: The prevention of COVID-19 pandemic is highly complicated by the prevalence of asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic and convalescent patients, while the immune responses in asymptomatic patients and re-detectable positive cases remain unclear. Methods: Here we comprehensively analyzed the peripheral T-cell receptor (TCR) repertoire of 54 COVID-19 patients in different phases, including asymptomatic, symptomatic, convalescent and re-detectable positive cases. Results: We found progressed immune responses from asymptomatic to symptomatic phase. Furthermore, the TCR profiles of re-detectable positive cases were highly similar to those of asymptomatic patients, which could predict the risk of recurrent infection. Conclusion: Therefore, TCR repertoire surveillance has the potential to strengthen the clinical management and the immunotherapy development for COVID-19.

中文翻译：

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无症状和可重新检测的阳性COVID-19患者的T细胞库特征

背景：由于无症状和复发感染的流行，对COVID-19大流行的预防非常复杂。先前的许多免疫学研究都集中在有症状和恢复期的患者上，而对无症状患者和可重新检测到的阳性病例的免疫反应仍不清楚。方法：在这里我们全面分析了54例COVID-19患者在不同阶段的外周T细胞受体（TCR）谱表，包括无症状，有症状，恢复期和可重新检测的阳性病例。结果：我们发现从无症状阶段到有症状阶段的免疫反应已经进展。此外，可重新检测到的阳性病例的TCR谱与无症状患者的TCR谱高度相似，这可以预测复发感染的风险。结论：因此，