Click chemistry has been established rapidly as one of the most valuable methods for the chemical transformation of complex molecules. Due to the rapid rates, clean conversions to the products, and compatibility of the reagents and reaction conditions even in complex settings, it has found applications in many molecule-oriented disciplines. From the vast landscape of click reactions, approaches have emerged in the past decade centered around oxidative processes to generate in situ highly reactive synthons from dormant functionalities. These approaches have led to some of the fastest click reactions know to date. Here, we review the various methods that can be used for such oxidation-induced “one-pot” click chemistry for the transformation of small molecules, materials, and biomolecules. A comprehensive overview is provided of oxidation conditions that induce a click reaction, and oxidation conditions are orthogonal to other click reactions so that sequential “click-oxidation-click” derivatization of molecules can be performed in one pot. Our review of the relevant literature shows that this strategy is emerging as a powerful approach for the preparation of high-performance materials and the generation of complex biomolecules. As such, we expect that oxidation-induced “one-pot” click chemistry will widen in scope substantially in the forthcoming years.

中文翻译：

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氧化诱导的“一锅法”点击化学

点击化学已迅速成为复杂分子化学转化的最有价值的方法之一。由于速度快、转化为产物的清洁度以及试剂和反应条件的兼容性，即使在复杂的环境中，它也已在许多面向分子的学科中得到应用。从点击反应的广阔领域来看，过去十年中出现了以氧化过程为中心的方法，以从休眠功能原位生成高反应性合成子。这些方法导致了迄今为止已知的一些最快的点击反应。在这里，我们回顾了可用于这种氧化诱导的“一锅”点击化学转化小分子、材料和生物分子的各种方法。提供了诱导点击反应的氧化条件的全面概述，氧化条件与其他点击反应正交，因此可以在一个锅中进行分子的顺序“点击-氧化-点击”衍生化。我们对相关文献的回顾表明，这种策略正在成为制备高性能材料和生成复杂生物分子的有力方法。因此，我们预计氧化诱导的“一锅”点击化学将在未来几年内大幅扩大范围。我们对相关文献的回顾表明，这种策略正在成为制备高性能材料和生成复杂生物分子的有力方法。因此，我们预计氧化诱导的“一锅”点击化学将在未来几年内大幅扩大范围。我们对相关文献的回顾表明，这种策略正在成为制备高性能材料和生成复杂生物分子的有力方法。因此，我们预计氧化诱导的“一锅”点击化学将在未来几年内大幅扩大范围。