Compounds containing hexavalent chromium [Cr(VI)] have been classified as Group I human carcinogens in 1990 by the International Agency for Research on Cancer, known to induce human lung cancers. To determine the nature of Cr(VI) carcinogenesis, much has been learned about genetic damage and epigenetic alterations. On the basis of bibliometric analysis of the available literature found between 1966 and 2020, the present study investigated the evolution of author keywords; provided a summary of relevant studies focused on populations, animals/plants, or cells; and depicted the co-operation among countries or institutions and research group development. Additionally, multiomics technology and bioinformatics analysis can be a valuable tool for figuring out new biomarkers from different molecular levels like gene, RNA, protein, and metabolite and ascertaining the mechanism pathways of Cr(VI) genotoxicity and carcinogenesis.

中文翻译：

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六价铬对遗传损伤和表观遗传改变的看法：基于文献计量分析的时间演化

国际癌症研究机构于 1990 年将含有六价铬 [Cr(VI)] 的化合物列为 I 类人类致癌物，已知会诱发人类肺癌。为了确定 Cr(VI) 致癌作用的性质，已经对遗传损伤和表观遗传改变有了很多了解。在对 1966 年至 2020 年间发现的可用文献进行文献计量分析的基础上，本研究调查了作者关键词的演变；提供了以种群、动物/植物或细胞为重点的相关研究的摘要；并描绘了国家或机构之间的合作以及研究团体的发展。此外，多组学技术和生物信息学分析可以成为从不同分子水平（如基因、RNA、蛋白质、