污染物传播、病毒-表面相互作用的物理化学起源以及包膜病毒的消毒策略及其在 SARS-CoV-2 中的应用,ACS Omega

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污染物传播、病毒-表面相互作用的物理化学起源以及包膜病毒的消毒策略及其在 SARS-CoV-2 中的应用
ACS Omega ( IF 4.1 ) Pub Date : 2021-03-05 , DOI: 10.1021/acsomega.0c06335
Nicolas Castaño ₁ , Seth C Cordts ₁ , Myra Kurosu Jalil ₁ , Kevin S Zhang ₁ , Saisneha Koppaka ₁ , Alison D Bick ₁ , Rajorshi Paul ₁ , Sindy K Y Tang ₁

Affiliation

被传染性病原体（称为污染物）污染的无生命物体或表面在病毒传播中发挥着重要作用，其中包括导致 COVID-19 大流行的病毒 SARS-CoV-2。病毒在表面上长期存在（数小时至数天），迫切需要有效的表面消毒策略来拦截病毒传播和疾病传播。阐明病毒在表面之间吸附和转移及其灭活的物理化学过程和表面科学，对于了解疾病如何传播和制定有效的干预策略非常重要。本综述总结了病毒传播（特别是通过污染物传播）的当前知识和基本物理化学过程以及常见的消毒方法。还确定了知识差距和需要进一步研究的领域。该综述的重点是 SARS-CoV-2，但鉴于对 SARS-CoV-2 的了解还很多，因此也包含了对相关病毒的讨论，以提供更全面的综述。我们的目标是，这篇综述将为广大读者提供有关污染物传播和干预所涉及问题的广泛调查，使他们能够更好地应对开放研究的挑战。

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Fomite Transmission, Physicochemical Origin of Virus–Surface Interactions, and Disinfection Strategies for Enveloped Viruses with Applications to SARS-CoV-2

Inanimate objects or surfaces contaminated with infectious agents, referred to as fomites, play an important role in the spread of viruses, including SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The long persistence of viruses (hours to days) on surfaces calls for an urgent need for effective surface disinfection strategies to intercept virus transmission and the spread of diseases. Elucidating the physicochemical processes and surface science underlying the adsorption and transfer of virus between surfaces, as well as their inactivation, is important for understanding how diseases are transmitted and for developing effective intervention strategies. This review summarizes the current knowledge and underlying physicochemical processes of virus transmission, in particular via fomites, and common disinfection approaches. Gaps in knowledge and the areas in need of further research are also identified. The review focuses on SARS-CoV-2, but discussion of related viruses is included to provide a more comprehensive review given that much remains unknown about SARS-CoV-2. Our aim is that this review will provide a broad survey of the issues involved in fomite transmission and intervention to a wide range of readers to better enable them to take on the open research challenges.

更新日期：2021-03-16

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