Cell migration is a cardinal feature of the immune system. Immune cell trafficking is orchestrated principally by chemokines and adhesion molecules, which guide the cells to the right place and at the right time to efficiently induce immune responses. Recent studies have demonstrated that signals from other organ systems influence the expression of and responsiveness to these guidance cues and consequentially immune cell migration. Neuronal inputs control entry and exit of immune cells to and from lymphoid and non-lymphoid tissues. The circadian clock helps establish diurnal variations in immune cell distribution among tissues. Nutritional status also alters immune cell homing to the bone marrow. In this review, we summarize the current knowledge about inter-organ control of immune cell trafficking and discuss the physiological and pathological significance of these mechanisms.

中文翻译：

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通过器官间通讯控制免疫细胞运输

细胞迁移是免疫系统的主要特征。免疫细胞运输主要由趋化因子和粘附分子协调，它们将细胞引导到正确的位置和正确的时间以有效地诱导免疫反应。最近的研究表明，来自其他器官系统的信号会影响这些指导线索的表达和反应，从而影响免疫细胞迁移。神经元输入控制免疫细胞进出淋巴和非淋巴组织。生物钟有助于建立组织间免疫细胞分布的昼夜变化。营养状况也会改变免疫细胞向骨髓的归巢。在本次审查中，