Abstract

OA is a complex and highly prevalent degenerative disease affecting the whole joint, in which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint destruction. ∼50–80% of OA patients develop synovitis. OA-associated risk factors contribute to joint instability and the release of cartilage matrix fragments, activating the synovium to release pro-inflammatory factors and catabolic enzymes in turn damaging the cartilage and creating a vicious circle. Currently, no cure is available for OA. Mesenchymal stromal cells (MSCs) have been tested in OA for their chondrogenic and anti-inflammatory properties. Interestingly, MSCs are most effective when administered during synovitis. This review focusses on the interplay between joint inflammation and the immunomodulation by MSCs in OA. We discuss the potential of MSCs to break the vicious circle of inflammation and describe current perspectives and challenges for clinical application of MSCs in treatment and prevention of OA, focussing on preventing post-traumatic OA.

中文翻译：

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结肠炎扩大了PAAND患者的表型

摘要

骨关节炎是影响整个关节的复杂且高度流行的退化性疾病，其中遗传易感性，性别，年龄，肥胖和外伤等因素导致关节破坏。约有50–80％的OA患者发展为滑膜炎。OA相关的危险因素导致关节不稳定和软骨基质碎片的释放，激活滑膜释放促炎因子和分解代谢酶，进而损害软骨并形成恶性循环。目前，尚无可用于OA的治疗方法。间充质基质细胞（MSCs）已在OA中进行了软骨形成和抗炎特性测试。有趣的是，在滑膜炎期间施用MSC最有效。这篇综述着重于OA中MSCs的关节炎症与免疫调节之间的相互作用。