Recent clinical studies showed that antiarrhythmic drug (AAD) treatment and pulmonary vein isolation (PVI) synergistically reduce atrial fibrillation (AF) recurrences after initially successful ablation. Among newly developed atrial-selective AADs, inhibitors of the G-protein-gated acetylcholine-activated inward rectifier current (I_KACh) were shown to effectively suppress AF in an experimental model but have not yet been evaluated clinically. We tested in silico whether inhibition of inward rectifier current or its combination with PVI reduces AF inducibility.

中文翻译：

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心房颤动 3D 计算机模型中内向整流电流抑制和肺静脉隔离的协同抗心律失常作用

最近的临床研究表明，抗心律失常药物 (AAD) 治疗和肺静脉隔离 (PVI) 可协同减少最初成功消融后的房颤 (AF) 复发。在新开发的心房选择性 AAD 中，G 蛋白门控乙酰胆碱激活的内向整流电流 ( I _KACh ) 的抑制剂在实验模型中显示可有效抑制 AF，但尚未在临床上进行评估。我们在计算机上测试了抑制内向整流器电流或其与 PVI 的组合是否会降低 AF 诱导性。