The aging population is at a higher risk for age-related diseases and infections. This observation could be due to immunosenescence: the decline in immune efficacy of both the innate and the adaptive immune systems. Age-related immune decline also links to the concept of ‘inflamm-aging,’ whereby aging is accompanied by sterile chronic inflammation. Along with a decline in immune function, aging is accompanied by a widespread of ‘omics’ remodeling. Transcriptional landscape changes linked to key pathways of immune function have been identified across studies, such as macrophages having decreased expression of genes associated to phagocytosis, a major function of macrophages. Therefore, a key mechanism underlying innate immune cell dysfunction during aging may stem from dysregulation of youthful genomic networks. In this review, we discuss both molecular and cellular phenotypes of innate immune cells that contribute to age-related inflammation.

中文翻译：

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炎症老化和免疫衰老的功能基因组学

老龄化人口患与年龄有关的疾病和感染的风险更高。这一观察结果可能是由于免疫衰老：先天性和适应性免疫系统的免疫功效均下降。与年龄相关的免疫衰退也与“炎症老化”的概念有关，老化伴随着无菌性慢性炎症。随着免疫功能的下降，衰老伴随着广泛的“组学”重塑。在研究中已经确定了与免疫功能关键途径相关的转录景观变化，例如巨噬细胞与吞噬作用相关的基因表达降低，吞噬作用是巨噬细胞的主要功能。因此，衰老过程中先天免疫细胞功能障碍的一个关键机制可能源于年轻基因组网络的失调。在本次审查中，