Objectives

Several epidemiological studies have evaluated association of interleukin 10 (IL-10) polymorphisms with risk of periodontitis. However, the results remain conflicting and inconclusive. Here, we carried out a comprehensive systematic review and meta-analysis to evaluate the association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with risk of chronic (CP) and aggressive (CP) periodontitis.

Methods

Electronic databases including PubMed, Science Direct, SciELO, and CNKI were systematically searched to identify all relevant studies published up to 01 June 2020.

Results

A total of 60 case–control studies with 5313 cases and 6528 controls met our inclusion criteria. Overall, the pooled data showed that the IL-10 -592C>A polymorphism was statistically associated with increased risk of periodontitis in the overall population, while no significant association was identified for IL-10 -1082A>G and IL-10 -819C>T polymorphisms. The subgroup analysis by ethnicity revealed that the IL-10 -1082A>G polymorphism was significantly associated with periodontitis risk in Caucasians, IL-10 -819C>T polymorphism in mixed population, and IL-10 -592C>A polymorphism in both Asians and mixed populations. When further analyzed by periodontitis type, only the IL-10 -592C>A polymorphism was associated with CP risk, but not AgP; and the IL-10 -1082A>G and -819C>T polymorphisms have not positive association neither in the CP and AgP.

Conclusions

The current meta-analysis showed that the IL-10 -592C>A polymorphism was statistically associated with periodontitis risk in the overall population. Moreover, the IL-10 -1082A>G, IL-10 -819C>T, and IL-10 -592C>A polymorphisms were associated with periodontitis risk by ethnicity. Therefore, the IL-10 polymorphisms are of high clinical relevance by ethnicity and would be a useful marker to identify patients who are at higher risk for periodontitis.

中文翻译：

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IL-10 -1082A>G、-819C>T 和 -592C>A 多态性与慢性侵袭性牙周炎易感性的关联：系统评价和荟萃分析

目标

几项流行病学研究评估了白介素 10 (IL-10) 多态性与牙周炎风险的关联。然而，结果仍然相互矛盾和不确定。在这里，我们进行了全面的系统评价和荟萃分析，以评估 IL-10 -1082A>G、-819C>T 和 -592C>A 多态性与慢性 (CP) 和侵袭性 (CP) 牙周炎风险的关联.

方法

系统搜索了包括 PubMed、Science Direct、SciELO 和 CNKI 在内的电子数据库，以识别截至 2020 年 6 月 1 日发表的所有相关研究。

结果

共有 60 项病例对照研究，其中 5313 例病例和 6528 例对照符合我们的纳入标准。总体而言，汇总数据显示 IL-10 -592C>A 多态性与整体人群中牙周炎风险增加具有统计学相关性，而未发现 IL-10 -1082A>G 和 IL-10 -819C> T 多态性。种族亚组分析显示，白种人中IL-10 -1082A>G多态性与牙周炎风险显着相关，混合人群中IL-10 -819C>T多态性与亚洲人和亚洲人中IL-10 -592C>A多态性显着相关。混合人群。进一步按牙周炎类型分析，只有IL-10 -592C>A多态性与CP风险相关，而与AgP无关；和 IL-10 -1082A>G 和 -819C>

结论

目前的荟萃分析表明，IL-10 -592C>A 多态性与整个人群中的牙周炎风险具有统计学相关性。此外，IL-10 -1082A>G、IL-10 -819C>T 和 IL-10 -592C>A 多态性与种族的牙周炎风险相关。因此，IL-10 多态性与种族具有高度的临床相关性，并且将是识别牙周炎风险较高的患者的有用标志物。