Objective Studies in rodents associated the deficits of adult hippocampal neurogenesis with behavioural anomalies which may be reversed by antidepressant treatments. A previous systematic review (SR) and meta-analysis (MA) indicated a hierarchy within the proneurogenic effects of different antidepressants in naive rodents. The present review aims to evaluate a more comprehensive sample of studies investigating the links between the effects of different antidepressants and adult hippocampal neurogenesis. Search strategy, screening annotation, data management Protocols were planned following Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. Searches in Embase, Medline, Scopus and Web of Science followed by screening with inclusion/exclusion criteria will provide relevant publications. First SR will summarise the effects of antidepressants on adult hippocampal neurogenesis on different laboratory rodents. Second SR will summarise the correlations between neurogenic and behavioural effects of antidepressants while the third will focus on cause–effect relationships between them. If feasible, data will be analysed by pairwise or network random-effect or multivariate MA to determine the direction, magnitude, significance and heterogeneity (I2) of the estimated effect sizes on global or subgroup levels. Funnel plotting, Egger regression, ‘trim and fill’ will be used to estimate the risk of publication bias. Quality assessment of the included publications will be performed by applying adapted CAMARADES, Syrcles’ risk of bias or CINeMA tools. Reporting Find a preliminary version of this protocol at the Open Science Framework (). Data extraction has already started. Results shall be published in a peer-reviewed journal. Due to the continuous production in the field, the implementation of a ‘living SR’ is intended.

中文翻译：

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对将海马神经发生与抗抑郁药对情绪和行为的影响联系起来的证据进行系统回顾和荟萃分析的协议

目的 对啮齿动物的研究将成年海马神经发生的缺陷与行为异常相关联，这些行为异常可以通过抗抑郁治疗来逆转。先前的系统评价 (SR) 和荟萃分析 (MA) 表明，不同抗抑郁药对幼稚啮齿动物的神经原性影响存在层次结构。本综述旨在评估更全面的研究样本，调查不同抗抑郁药的影响与成人海马神经发生之间的联系。搜索策略、筛选注释、数据管理协议是按照系统审查和 Meta 分析协议指南的首选报告项目计划的。在 Embase、Medline、Scopus 和 Web of Science 中搜索，然后使用纳入/排除标准进行筛选，将提供相关出版物。First SR 将总结抗抑郁药对不同实验室啮齿动物成年海马神经发生的影响。第二个 SR 将总结抗抑郁药的神经源性和行为效应之间的相关性，而第三个将重点关注它们之间的因果关系。如果可行，将通过成对或网络随机效应或多变量 MA 分析数据，以确定估计效应大小在全局或亚组水平上的方向、幅度、显着性和异质性 (I2)。漏斗图、Egger 回归、“修剪和填充”将用于估计发表偏倚的风险。将通过应用改编的 CAMARADES、Syrcles 的偏倚风险或 CINeMA 工具对所包含的出版物进行质量评估。报告 在 Open Science Framework (）。数据提取已经开始。结果应在同行评审期刊上发表。由于该领域的持续生产，因此打算实施“生活 SR”。