Introduction: Evidence favoring homeopathy in generalized anxiety disorder (GAD) remains scarce. The objective of this pilot trial was to test feasibility of a definitive trial in future. We also experimented whether individualized homeopathic medicines (IH) plus psychological counseling (PC) can produce significantly different effects beyond placebo plus PC in the treatment of GAD. Methods: A double-blind, randomized, placebo-controlled, parallel arm, pilot trial was conducted on 62 GAD patients at the National Institute of Homoeopathy, India. GAD-7 questionnaire and Hamilton Anxiety Scale (HAM-A) were used as the primary and secondary outcomes, respectively, measured at baseline and 3 months. Patients received either IH plus PC (n = 31) or identical-looking placebo plus PC (n = 31). Intention-to-treat sample was analyzed to detect group differences using unpaired t tests. Results: Recruitment and retention rates were 56 and 90%, respectively. Mean age was 31.5 years; 56.5% were male. GAD-7 reductions were non-significantly higher in IH than placebo (p = 0.122). Group differences on HAM-A favored IH significantly (p = 0.018). Effect sizes were small to medium. Calcarea carbonica was the most frequently indicated medicine. No serious adverse events happened. Conclusions: A small but positive direction of anxiolytic effect was observed favoring homeopathy over placebo. A definitive trial appeared feasible in future.
Complement Med Res

中文翻译：

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个体化顺势疗法药物治疗广泛性焦虑症：一项双盲、随机、安慰剂对照、试验性试验

简介：支持顺势疗法治疗广泛性焦虑症 (GAD) 的证据仍然很少。该试点试验的目的是测试未来最终试验的可行性。我们还试验了个体化顺势疗法药物 (IH) 加心理咨询 (PC) 是否能在 GAD 治疗中产生明显不同于安慰剂加 PC 的效果。方法：在印度国家顺势疗法研究所对 62 名 GAD 患者进行了一项双盲、随机、安慰剂对照、平行臂试验性试验。GAD-7 问卷和汉密尔顿焦虑量表 (HAM-A) 分别用作主要和次要结果，分别在基线和 3 个月时测量。患者接受 IH 加 PC（ n= 31) 或外观相同的安慰剂加 PC ( n = 31)。使用非配对t检验分析意向治疗样本以检测组间差异。结果：招聘率和保留率分别为 56% 和 90%。平均年龄为 31.5 岁；56.5% 是男性。IH 中 GAD-7 的降低不显着高于安慰剂（p = 0.122）。HAM-A 的组差异显着地有利于 IH ( p = 0.018)。效果大小从小到中。Calcarea carbonica是最常使用的药物。没有发生严重的不良事件。结论：观察到抗焦虑作用的一个小但积极的方向有利于顺势疗法而不是安慰剂。未来的最终试验似乎是可行的。
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