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Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain [Neuroscience]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2021-03-09 , DOI: 10.1073/pnas.2019826118
Annika F Barber 1 , Shi Yi Fong 2, 3 , Anna Kolesnik 2, 3 , Michael Fetchko 1 , Amita Sehgal 3, 4
Affiliation  

Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions, but the mechanism by which clock cells regulate downstream targets is not known. We show here that the pars intercerebralis (PI), previously identified as a target of the morning cells in the clock network, also receives input from evening cells. We determined that morning and evening clock neurons have time-of-day–dependent connectivity to the PI, which is regulated by specific peptides as well as by fast neurotransmitters. Interestingly, PI cells that secrete the peptide DH44, and control rest:activity rhythms, are inhibited by clock inputs while insulin-producing cells (IPCs) are activated, indicating that the same clock cells can use different mechanisms to drive cycling in output neurons. Inputs of morning cells to IPCs are relevant for the circadian rhythm of feeding, reinforcing the role of the PI as a circadian relay that controls multiple behavioral outputs. Our findings provide mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.



中文翻译:

果蝇时钟细胞使用多种机制在大脑中传输时间信号 [神经科学]

果蝇对昼夜节律行为和生理的调节大脑时钟需要从中央时钟神经元到下游输出区域的通信,但时钟细胞调节下游目标的机制尚不清楚。我们在这里展示了之前被确定为时钟网络中晨间细胞目标的脑间部 (PI),也接收来自晚间细胞的输入。我们确定早晨和晚上的时钟神经元与 PI 具有时间依赖性连接,PI 受特定肽以及快速神经递质调节。有趣的是,分泌肽 DH44 并控制休息:活动节律的 PI 细胞受到时钟输入的抑制,而产生胰岛素的细胞 (IPC) 被激活,这表明相同的时钟细胞可以使用不同的机制来驱动输出神经元的循环。晨间细胞对 IPC 的输入与进食的昼夜节律有关,加强了 PI 作为控制多个行为输出的昼夜节律继电器的作用。我们的发现提供了时钟神经元向非时钟细胞发出信号以驱动行为节律的机制。

更新日期:2021-03-04
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