Omeprazole has been widely used in the horse for nearly 20 years. Yet, to date, few studies have evaluated its safety with specific regards to the adverse effects reported in human medicine. Recent studies on omeprazole in the horse have highlighted the potential for rebound gastric hyperacidity at the time of discontinuation of therapy, for decreased calcium absorption during administration and for disruption to hindgut function when administered alongside non-steroidal anti-inflammatory drugs. Unlike human medicine, no clear evidence exists for a link between omeprazole administrations and an increased risk of fractures in the horse. However, evidence exists that the proposed pathophysiological pathways for increased fracture risk which are present in human medicine are also present in the horse. Limited evidence suggests that decreased efficacy may occur over time with long-term omeprazole administration.

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搭便车：长期服用奥美拉唑治疗安全有效吗？

奥美拉唑已广泛用于马匹近20年。然而，迄今为止，很少有研究评估其安全性，特别是在人类医学中报告的不良反应方面。最近对马使用奥美拉唑的研究强调了在停止治疗时出现胃酸过多反跳、给药期间钙吸收减少以及与非甾体抗炎药一起给药时后肠功能破坏的可能性。与人类医学不同，没有明确的证据表明奥美拉唑给药与马骨折风险增加之间存在联系。然而，有证据表明，人类医学中提出的增加骨折风险的病理生理学途径也存在于马身上。