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Antimicrobial minimum inhibitory concentration of Mycoplasma gallisepticum: a systematic review
Journal of Applied Poultry Research ( IF 1.9 ) Pub Date : 2021-03-04 , DOI: 10.1016/j.japr.2021.100160
H. Taiyari , N.M. Faiz , J. Abu , Z. Zakaria

The aptitude of Mycoplasma gallisepticum (MG) for changing its surface proteins allows the pathogen to reduce the efficacy of antimicrobial agents, especially those targeting surface proteins. Although antibiotic treatment cannot be a solution for the eradication of avian mycoplasmosis, it can be considered a good option to minimize the number of deaths. One of the challenges of antibiotic treatments is the development of antimicrobial resistance (AMR) among field isolates. Monitoring the antimicrobial susceptibility profile of field isolates can be a practical way of avoiding AMR. Thus, various tests have been developed to determine the antimicrobial susceptibility profile of field isolates. A modified broth microdilution minimum inhibitory concentration (MIC) test has been regularly used to measure the antimicrobial susceptibility profile of MG field isolates. Numerous studies have reported an increase in the number of antibiotic-resistant field isolates of MG. Therefore, this study presents a systematic review on antimicrobial MIC values of MG isolates to gather recent knowledge and investigate the prevalence and distribution of AMR among MG field isolates. A thorough search was conducted for related studies throughout 3 electronic databases. Altogether, 23 studies were identified as eligible studies and were used for further analysis. The results showed that enrofloxacin, oxytetracycline, and tylosin had the highest number of resistant isolates in most of the geographical distributions, respectively. Minimum inhibitory concentrations of these antibiotics need to be determined regularly to optimize treatment dosages.



中文翻译:

鸡支原体的抗菌最低抑菌浓度:系统评价

的性向鸡毒支原体MG),用于改变它的表面蛋白允许病原体减少抗微生物剂的功效,尤其是那些靶向表面蛋白。尽管抗生素治疗不能成为根除禽支原体病的解决方案,但可以将其视为减少死亡人数的好选择。抗生素治疗的挑战之一是在田间分离株中产生抗药性(AMR)。监测现场分离株的抗菌药敏性可以是避免AMR的一种实用方法。因此,已经开发了各种测试来确定现场分离株的抗药性。改良肉汤微稀释液的最小抑菌浓度(麦克风)测试已被常规用于测量MG现场分离株的抗菌药敏性。大量研究报告称,MG的抗生素抗药性现场分离株数量有所增加。因此,本研究对MG菌株的抗菌MIC值进行了系统综述,以收集最新知识并调查MG菌株中AMR的流行和分布。在3个电子数据库中进行了彻底的检索以寻找相关研究。共有23项研究被鉴定为合格研究,并用于进一步分析。结果表明,恩诺沙星,土霉素和泰乐菌素在大多数地理分布中分别具有最高的耐药菌株数量。

更新日期:2021-04-04
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