Molecular & Cellular Toxicology ( IF 1.7 ) Pub Date : 2021-03-03 , DOI: 10.1007/s13273-021-00127-8 Sung-Hwa Sohn , Hee Jung Sul , Yeonsong Choi , Semin Lee , Bum Jun Kim , Hyeong Su Kim , Youngho Koh , Dae Young Zang
Backgrounds
Gastric cancer (GC), a prevalent malignancy in Eastern Asia, is associated with aberrant transcriptional regulation.
Objective
Here, we evaluated the mRNA and microRNA transcriptomes in patients with gastric cancer to gain insight into the molecular underpinnings of this disease.
Results
We observed upregulation of inhibin βA (INHBA), CDC7, SULF1, COL11A1, KIAA1199, and CLDN1 transcripts in gastric cancer and showed that INHBA upregulation was associated with cancer recurrence. Expression of has-miR-135a-5p was significantly lower in gastric cancer tissues compared with matched normal tissues and was inversely associated with INHBA expression.
Conclusion
Our findings suggest that INHBA and has-miR-135a-5p expression serve as therapeutic markers of gastric cancer recurrence.
中文翻译:
整合的mRNA-microRNA调控网络将INHBA和has-miR-135a-5p识别为胃癌复发的预测因子
背景资料
胃癌(GC)是东亚地区普遍存在的恶性肿瘤,与转录调控异常有关。
客观的
在这里,我们评估了胃癌患者的mRNA和microRNA转录组,以深入了解该疾病的分子基础。
结果
我们观察到胃癌中抑制素βA(INHBA),CDC7,SULF1,COL11A1,KIAA1199和CLDN1转录本的上调,并表明INHBA上调与癌症复发相关。与匹配的正常组织相比,在胃癌组织中has-miR-135a-5p的表达明显较低,并且与INHBA表达呈负相关。
结论
我们的发现表明,INHBA和has-miR-135a-5p表达可作为胃癌复发的治疗指标。