Vascular calcification occurs highly prevalent, which commonly predicts adverse cardiovascular events. The pathogenesis of calcification, a complicated and multifactorial process, is incompletely characterized. Accumulating evidence shows that mitochondrial dysfunction may ultimately be more detrimental in the vascular smooth muscle cells (VSMCs) calcification. This review summarizes the role of mitochondrial dysfunction and metabolic reprogramming in vascular calcification, and indicates that metabolic regulation may be a therapeutic target in vascular calcification.

中文翻译：

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线粒体稳态和血管内侧钙化

血管钙化非常普遍，这通常预示着不良心血管事件。钙化的发病机制是一个复杂的多因素过程，尚未完全表征。越来越多的证据表明，线粒体功能障碍最终可能对血管平滑肌细胞 (VSMCs) 钙化更加有害。本综述总结了线粒体功能障碍和代谢重编程在血管钙化中的作用，并表明代谢调节可能是血管钙化的治疗靶点。