Non-anatomical placement may occur during the surgical implantation of the meniscal implant, and its influence on the resulting biomechanics of the knee joint has not been systematically studied. The purpose of this study was to evaluate the biomechanical effects of non-anatomical placement of the meniscal implant on the knee joint during a complete walking cycle. Three-dimensional finite element (FE) analyses of the knee joint were performed, based on the model developed from magnetic resonance images and the loading conditions derived from the gait pattern of a healthy male subject, for the following physiological conditions: (i) knee joint with intact native meniscus, (ii) medial meniscectomized knee joint, (iii) knee joint with anatomically placed meniscal implant, and (iv) knee joint with the meniscal implant placed in four different in vitro determined non-anatomical locations. While the native menisci were modeled using the nonlinear hyperelastic Holzapfel–Gasser–Ogden (HGO) constitutive model, the meniscal implant was modeled using the isotropic hyperelastic neo-Hookean model. Placement of the meniscal implant in the non-anatomical lateral-posterior and lateral-anterior locations significantly increased the peak contact pressure in the medial compartment. Placement of the meniscal implant in non-anatomical locations significantly altered the tibial rotational kinematics and increased the total force acting at the meniscal horns. Results suggest that placement of the meniscal implant in non-anatomical locations may restrain its ability to be chondroprotective and may initiate or accelerate cartilage degeneration. In conclusion, clinicians should endeavor to place the implant as closest as possible to the anatomical location to restore the normal knee biomechanics.

半月板植入手术过程中可能会出现非解剖位置，其对膝关节生物力学的影响尚未得到系统研究。本研究的目的是评估在一个完整的步行周期中半月板植入物在膝关节上的非解剖位置的生物力学影响。基于从磁共振图像开发的模型和从健康男性受试者的步态模式得出的负载条件，对膝关节进行了三维有限元 (FE) 分析，用于以下生理条件：(i) 膝关节具有完整天然半月板的关节，(ii) 内侧半月板切除的膝关节，(iii) 具有解剖学放置的半月板植入物的膝关节，(iv) 膝关节，半月板植入物放置在四个不同的体外确定的非解剖位置。使用非线性超弹性 Holzapfel-Gasser-Ogden (HGO) 本构模型对天然半月板进行建模，而使用各向同性超弹性新胡克模型对半月板植入物进行建模。将半月板植入物放置在非解剖学的外侧-后和外侧-前位置显着增加了内侧隔室中的峰值接触压力。将半月板植入物放置在非解剖位置显着改变了胫骨旋转运动学并增加了作用在半月板角上的总力。结果表明，将半月板植入物放置在非解剖位置可能会限制其保护软骨的能力，并可能引发或加速软骨退化。总之，临床医生应努力将植入物放置在尽可能靠近解剖位置的位置，以恢复正常的膝关节生物力学。