Three different 4-propargyloxychalcones have been prepared starting from 4-propargyloxy benzaldehyde and chalcones with proper chemical transformation. Polystyrenes containing biologically active chalcone moiety in their structures have been successfully synthesised by the Click reaction from the 4-propargyloxychalones (terminal alkyne) and azido end-functional polystyrene (PS-N₃). All the desired products have been obtained with good yield and purity. The structure of the 4-propargyloxychalcones and the chalcone containing polystyrenes have been characterized by FT-IR, ¹H NMR and UV-Vis spectroscopy. The antibacterial activity of the synthesized 4-propargyloxychalcones their polystyrene derivatives have been evaluated against two bacterial strains, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The results reveal that the tested chalcones and their polystyrene derivatives have moderate antimicrobial activity.

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含查尔酮的聚苯乙烯的合成及抑菌活性

从4-炔丙氧基苯甲醛和查耳酮开始，已经制备了三种不同的4-炔丙氧基查耳酮，并进行了适当的化学转化。通过Click反应，由4-炔丙基氧基查诺酮（末端炔烃）和叠氮基末端官能聚苯乙烯（PS-N ₃）成功地合成了结构中含有生物活性查耳酮部分的聚苯乙烯。已经以良好的产率和纯度获得了所有期望的产物。通过FT-IR，¹ H NMR和UV-Vis光谱法表征了4-炔丙基氧基查耳酮和含查尔酮的聚苯乙烯的结构。已经评估了合成的4-炔丙基氧基查耳酮及其聚苯乙烯衍生物对两种细菌菌株金黄色葡萄球菌的抗菌活性。（革兰氏阳性）和大肠杆菌（革兰氏阴性）。结果表明，所测试的查耳酮及其聚苯乙烯衍生物具有中等的抗菌活性。