Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriatic patients experience accelerated aging. As accelerated aging might be the reason for the higher prevalence of comorbidities at lower chronological ages, we also wanted to investigate the relationship between aging and selected parameters of frequent psoriatic comorbidities - endocan, vascular endothelial growth factor and interleukin-17. Samples were obtained from 28 patients and 42 healthy controls. Epigenetic age measurement was based on the Horvath clock. The levels of endocan, vascular endothelial growth factor and interleukin-17 were analyzed using standardized ELISA methods. The difference between the epigenetic age and the chronological age of each individual subject did not increase with the increasing chronological age of patients. We cannot conclude that psoriasis causes accelerated aging. However, the epigenetic and chronological age difference was significantly higher in female patients than in female controls, and the difference was correlated with endocan (r = 0.867, p = 0.0012) and vascular endothelial growth factor (r = 0.633, p = 0.0365) only in female patients. The findings suggest a possible presence of pathophysiological processes that occur only in female psoriatic patients. These processes make psoriatic females biologically older and might lead to an increased risk of comorbidity occurrence. This study also supports the idea that autoimmune diseases cause accelerated aging, which should be further explored in the future.

中文翻译：

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寻常型牛皮癣的老化：女性患者在表观遗传上比健康对照组大

寻常型牛皮癣是一种皮肤自身免疫性疾病。银屑病患者的预期寿命大大降低，并患有各种合并症。该研究的主要目的是确定银屑病患者是否经历加速衰老。由于加速衰老可能是在较低的年龄组中合并症患病率较高的原因，因此我们也想研究衰老与频繁的银屑病合并症所选参数之间的关系，即内皮糖，血管内皮生长因子和白介素-17。从28名患者和42名健康对照者中获得样品。表观遗传的年龄测量基于Horvath时钟。使用标准化的ELISA方法分析了内皮糖，血管内皮生长因子和白介素17的水平。每个个体受试者的表观遗传年龄和时间年龄之间的差异并未随患者时间年龄的增加而增加。我们不能得出结论，牛皮癣会加速衰老。然而，女性患者的表观遗传和年龄差异显着高于女性对照，并且该差异仅与内皮糖（r = 0.867，p = 0.0012）和血管内皮生长因子（r = 0.633，p = 0.0365）相关。在女性患者中。这些发现表明，仅在女性银屑病患者中可能存在病理生理过程。这些过程使银屑病女性在生物学上变老，并可能导致合并症的风险增加。这项研究还支持以下观点：自身免疫性疾病会加速衰老，